Fetal alcohol spectrum disorders in young adulthood
Fetal alcohol spectrum disorders in young adulthood
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DOI：
10.1016/j.jpeds.2006.11.044
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发表时间：
2007-02-01
影响因子：
5.1
通讯作者：
Steinhausen, Hans-Christoph
中科院分区：
文献类型：
--
作者：
Spohr, Hans-Ludwig;Willms, Judith;Steinhausen, Hans-Christoph
目的：为了检验胎儿酒精综合征（FAS）（具有完整的表型）和胎儿酒精效应（FAE）（具有部分但非全部特征）可以在胎儿酒精谱系障碍（FASD）的保护伞术语下组合的假设。我们调查了宫内酒精暴露的长期后遗症，以及对37名最初被诊断为婴儿期和儿童期患有FAS或FAE的FASD患者进行的20年随访研究中的行为脸颊列表。结果：虽然FAS/FAE的特征性颅面畸形随着时间的推移而减少，但小头畸形、人中发育不良和上唇薄，身材矮小和体重不足（男孩）的情况仍然存在，但程度较轻。在雌性中，成年体重增加。持续的精神障碍，包括智力残疾，有限的职业选择，和依赖的生活，是主要的后遗症，和各种行为问题的分数显着increasing.Conclusions：宫内暴露于酒精的破坏性影响持续到成年早期，严重限制职业生涯和独立生活。
Objective: To test the hypothesis that fetal alcohol syndrome (FAS), with the full phenotype, and fetal alcohol effect (FAE), with some but not all of the features, can be combined under the umbrella term fetal alcohol spectrum disorders (FASD).Study design: We investigated the long-term sequelae of intrauterine alcohol exposure rising physical examination, psychosocial interviews, and a behavioral cheeklist in a 20-year follow-up study of 37 patients with FASD originally diagnosed as having FAS or FAE in infancy and childhood.Results: Although the characteristic craniofacial malformations of FAS/FAE diminish over time, microcephaly, a poorly developed philtrum and a thin upper lip, and, to a lesser degree, short stature and underweight (in boys) persist. In females, adult body weight increases. Persistent mental handicaps, including intellectual disability, limited occupational options, and dependent living, are the major sequelae, and the scores for various behavioral problems are significantly increased.Conclusions: The devastating effects of intrauterine exposure to alcohol persist into early adulthood and severely limit careers and independent living.