Effects of oxycodone pharmacogenetics on postoperative analgesia and related clinical outcomes in children: a pilot prospective study.
Effects of oxycodone pharmacogenetics on postoperative analgesia and related clinical outcomes in children: a pilot prospective study.
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DOI：
10.2217/pgs-2022-0149
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发表时间：
2023-03
期刊：
影响因子：
2.1
通讯作者：
B. W. Aruldhas;S. Quinney;Senthil Packiasabapathy;B. Overholser;Olivia Raymond;Sahana Sivam;Inesh Sivam;Sanjana Velu;Antoinette Montelibano;S. Sadhasivam
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文献类型：
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作者：
B. W. Aruldhas;S. Quinney;Senthil Packiasabapathy;B. Overholser;Olivia Raymond;Sahana Sivam;Inesh Sivam;Sanjana Velu;Antoinette Montelibano;S. Sadhasivam
Background: Variability in the pharmacokinetics and pharmacodynamics of oxycodone in children undergoing surgery could be due to genetic polymorphisms. Materials & methods: The authors studied the association between clinical outcomes and pharmacogenes in children undergoing major surgery. A total of 89 children (35 undergoing pectus excavatum repair and 54 undergoing spinal fusion) were recruited. Results: OPRM1 SNP rs6902403 showed an association with maximum pain score and total morphine equivalent dose (p < 0.05). Other polymorphisms in OPRM1 SNP, PXR, COMT and ABCB1 were also shown to be associated with average morphine equivalent dose, length of hospital stay and maximum surgical pain (p < 0.05). Conclusion: This study demonstrates novel associations between the above pharmacogenes and oxycodone's pharmacokinetics as well as postoperative outcomes in children. Clinical trial registration: NCT03495388 (ClinicalTrials.gov).
