Bad Smells and Broken DNA: A Tale of Sulfur-Nucleic Acid Cooperation.
Bad Smells and Broken DNA: A Tale of Sulfur-Nucleic Acid Cooperation.
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DOI：
10.3390/antiox10111820
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发表时间：
2021-11-17
期刊：
影响因子：
--
通讯作者：
Kevil CG
中科院分区：
文献类型：
--
作者：
Shackelford RE;Li Y;Ghali GE;Kevil CG
硫化氢（H2S）是一种气体递质，具有多种生理和病理生理作用。最近，已经确定了H2S在DNA修复中的作用，其中H2S调节细胞周期检查点反应、DNA损伤反应（DDR）以及线粒体和核基因组稳定性。此外，几种DNA修复蛋白调节细胞H2S浓度和细胞硫代谢，并且反过来受细胞H2S浓度调节。许多DDR蛋白现在在靶向癌症治疗中被抑制。由于H2S和合成它的酶在许多人类恶性肿瘤中增加，因此这些疗法对H2S合成的抑制可能是这些癌症治疗的一个未被充分认识的方面。此外，H2S和DDR蛋白在癌症和心血管疾病中的活性正变得越来越明显，暗示DDR-H2S信号传导轴在这些病理生理过程中。总之，H2S和DNA修复可能在正常细胞功能和广泛的人类病理生理过程中发挥核心作用，但目前了解甚少。在这里，我们回顾一下H2S在DNA修复中的作用。
Hydrogen sulfide (H2S) is a gasotransmitter that exerts numerous physiologic and pathophysiologic effects. Recently, a role for H2S in DNA repair has been identified, where H2S modulates cell cycle checkpoint responses, the DNA damage response (DDR), and mitochondrial and nuclear genomic stability. In addition, several DNA repair proteins modulate cellular H2S concentrations and cellular sulfur metabolism and, in turn, are regulated by cellular H2S concentrations. Many DDR proteins are now pharmacologically inhibited in targeted cancer therapies. As H2S and the enzymes that synthesize it are increased in many human malignancies, it is likely that H2S synthesis inhibition by these therapies is an underappreciated aspect of these cancer treatments. Moreover, both H2S and DDR protein activities in cancer and cardiovascular diseases are becoming increasingly apparent, implicating a DDR–H2S signaling axis in these pathophysiologic processes. Taken together, H2S and DNA repair likely play a central and presently poorly understood role in both normal cellular function and a wide array of human pathophysiologic processes. Here, we review the role of H2S in DNA repair.
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