Aerosol-Based Fabrication of Biocompatible Organic-Inorganic Nanocomposites
Aerosol-Based Fabrication of Biocompatible Organic-Inorganic Nanocomposites
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DOI：
10.1021/am300337c
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发表时间：
2012-05-01
影响因子：
9.5
通讯作者：
Roberts, Jeffrey T.
中科院分区：
文献类型：
--
作者：
Byeon, Jeong Hoon;Roberts, Jeffrey T.
Several novel nanoparticle composites were conveniently obtained by appropriately reacting freshly produced aerosol metal nanoparticles with soluble organic components. A serial reactor consisting of a spark particle generator coupled to a collison atomizer was used to fabricate the new materials, which included nanomagnetosols (comprising iron nanoparticles, the drug ketoprofen, and a Eudragit shell), hybrid nanogels (comprising iron nanoparticles and an N-isopropylacrylamide, NIPAM, gel), and nanoinorganics (gold immobilized silica). A fourth hybrid material, consisting of iron-gold nanoparticles and NIPAM) was obtained via an aerosol into liquid configuration, in which aerosol iron-gold particles were collected into a NIPAM/ethanol solution and then formed into nanogels with NIPAM under ultrasonic treatment. The strategy outlined in this work is potentially generalizable as a new platform for creating biocompatible nanocomposites, using only clinically approved starting materials in a single pass and under low-temperature conditions.
