Viral clearance without destruction of infected cells during acute HBV infection
Viral clearance without destruction of infected cells during acute HBV infection
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DOI：
10.1126/science.284.5415.825
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发表时间：
1999-04-30
期刊：
影响因子：
56.9
通讯作者：
Chisari, FV
中科院分区：
文献类型：
--
作者：
Guidotti, LG;Rochford, R;Chisari, FV
乙肝病毒感染过程中的病毒清除被认为反映了CD8(+)T淋巴细胞对感染的肝细胞的破坏。然而，在这项研究中，急性感染的黑猩猩的肝脏和血液中的HBVDNA被证明在T细胞渗透的高峰期和大多数肝脏疾病之前很久就消失了。这些结果表明，在急性病毒性肝炎期间，非细胞病理性抗病毒机制通过清除感染细胞胞浆中的病毒复制中间产物和感染细胞核中的共价闭合环状病毒DNA来促进病毒清除。
Viral clearance during hepatitis B virus (HBV) infection has been thought to reflect the destruction of infected hepatocytes by CD8(+) T lymphocytes. However, in this study, HBV DNA was shown to Largely disappear from the Liver and the blood of acutely infected chimpanzees Long before the peak of T cell infiltration and most of the Liver disease. These results demonstrate that noncytopathic antiviral mechanisms contribute to viral clearance during acute viral hepatitis by purging HBV replicative intermediates from the cytoplasm and covalently closed circular viral DNA from the nucleus of infected cells.