Polymorphisms of CYP1A1, CYP2E1, GSTM1, GSTT1, and TP53 genes in Amerindians
Polymorphisms of CYP1A1, CYP2E1, GSTM1, GSTT1, and TP53 genes in Amerindians
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DOI：
10.1002/ajpa.10128
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发表时间：
2002-11-01
影响因子：
2.8
通讯作者：
Weimer, TA
中科院分区：
文献类型：
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作者：
Gaspar, PA;Hutz, MH;Weimer, TA
TP53、细胞色素 P-450 (CYP) 和谷胱甘肽 S-转移酶 (GST) 基因的多态性与癌症易感性相关，并且在种族群体中等位基因频率呈现高度多样性。本研究涉及七个美洲印第安人群体（Xavante、Guarani、Ache、Wai Wai、Zoro、Surui 和 Gaviao）的 CYP2E1、GSTM1 和 GSTT1 多态性。还在 Ache 和 Guarani 部落中研究了 CYP1A1 和 TP53 的多态性位点，并与之前在其他人群中获得的有关这些系统的结果进行了比较。 CYP2E1*5B 单倍型分别显示了在人类群体中观察到的最高和最低频率。观察到 CYP1A1*2A 和 CYP1A1*2C 等位基因频率较高，而 GSTM1*0/*0 和 GSTT1*0/*0 基因型值大多较低。这些数据可能被解释为是由于美国殖民期间对这些高频 CYP1A1 等位基因和 GST 无效基因型的遗传漂变或选择造成的。种群内多样性从 0.19（瓜拉尼）到 0.38（苏瑞）不等，总多样性的 90% 是由于种群内的变异性造成的。这些美洲印第安人与其他种族群体之间的关系是根据 D-A 距离和邻接法进行评估的。遗传关系与地理距离或语言群体之间的相关性较低。在TP53与其他族群的比较中，美洲印第安人聚集在一起，然后加入华人群体。聚类分析似乎表明，阿奇部落可能是一个Ge族的后裔，该族可能首先在巴拉圭地区殖民，但也可能通过部落间的混合吸收了一定量的瓜拉尼基因库。 (C) 2002 Wiley-Liss, Inc.
Polymorphisms at the TP53, cytochrome P-450 (CYP), and glutathione S-transferase (GST) genes are related to cancer susceptibility and present high diversity in allele frequencies among ethnic groups. This study concerns the CYP2E1, GSTM1, and GSTT1 polymorphisms in seven Amerindian populations (Xavante, Guarani, Ache, Wai Wai, Zoro, Surui, and Gaviao). Polymorphic sites at CYP1A1 and TP53 were also studied in the Ache and Guarani tribes and compared with previous results about these systems already obtained in the other populations. The CYP2E1*5B haplotype showed, respectively, the highest and the lowest frequencies already observed in human groups. High frequencies of CYP1A1*2A and CYP1A1*2C alleles and mostly low values of GSTM1*0/*0 and GSTT1*0/*0 genotypes were observed. These data may be interpreted as being due to genetic drift or selection for these high-frequency CYP1A1 alleles and against GST null genotypes during America's colonization. Intrapopulation diversity varied from 0.19 (Guarani) to 0.38 (Surui), and 90% of the total diversity was due to the variability within populations. The relationships between these Amerindians and with other ethnic groups were evaluated based on D-A distances and the neighbor-joining method. Low correlation was observed between genetic relationships and geographic distances or linguistic groups. In the TP53 comparison with other ethnic groups, Amerindians clustered together and then joined Chinese populations. The cluster analysis seems to indicate that the Ache tribe might descend from a Ge group that could have first colonized that Paraguayan region, but had also assimilated some amount of the Guarani gene pool, maybe through intertribal admixture. (C) 2002 Wiley-Liss, Inc.