Novel insights into coronary lumen preservation during progression of coronary atherosclerosis in coronary atherosclerosis-prone rabbits
Novel insights into coronary lumen preservation during progression of coronary atherosclerosis in coronary atherosclerosis-prone rabbits
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DOI：
10.1097/00019501-200411000-00009
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发表时间：
2004-11-01
影响因子：
1.8
通讯作者：
Gould, KL
中科院分区：
文献类型：
--
作者：
Shiomi, M;Ito, T;Gould, KL
研究背景在冠状动脉粥样硬化易感性Watanabe遗传性高脂血症（WHHLCA）兔中，低密度脂蛋白受体缺乏和自发性冠状动脉粥样硬化的动物模型，冠状动脉在动脉粥样硬化进展过程中表现出代偿性重塑。因此，我们分析了冠状动脉重塑的WHHLCA兔定量使用的方法，消除了以前的分析methods.Methods的局限性，在灌注固定的冠状动脉的11 WHHLCA兔使用新的和以前的分析进行了评估。改进后的方法消除了定量分析动脉重塑的局限性，我们评估了与斑块形成前相比，管腔面积或动脉大小如何随着动脉粥样硬化斑块的积累而变化。使用直径-长度关系计算斑块形成前的原始管腔面积。从动脉size.Results的变化计算壁剪切应力变化率使用旧的分析方法（和类似的人类研究中看到的），管腔面积增加到29%的横截面狭窄的水平。然而，在改进的分析中，在低于10%的横截面狭窄水平下，管腔面积适度减小，并且当横截面狭窄范围为10- 68%时，管腔面积保持恒定，并且当横截面狭窄达到70%或以上时，尽管持续重塑，但管腔面积急剧减小。动脉重塑的进展定量的动脉壁剪切应力以及管腔面积的轻微增加到70%的水平的横截面narrowing.Conclusions这些研究结果表明显着的影响，动脉锥形和个体差异的动脉大小的定量分析动脉重塑，并提供了新的见解，即动脉粥样硬化中的冠状动脉代偿性重塑将管腔大小维持在70%交叉水平，截面变窄与壁面剪应力成比例。(C)2004年利平科特威廉姆斯威尔金斯。
Background In coronary atherosclerosis-prone Watanabe heritable hyperlipidaemic (WHHLCA) rabbits, an animal model for low-density lipoprotein receptor deficiency and spontaneous coronary atherosclerosis, the coronary arteries show compensatory remodelling during the progression of atherosclerosis. Therefore, we analysed coronary remodelling of WHHLCA rabbits quantitatively using a method that eliminates the limitations of previous analytical methods.Methods Arterial remodelling was evaluated in perfusion-fixed coronary arteries of 11 WHHLCA rabbits using both new and previous analyses. With the improved methods removing limitations on quantitative analysis of arterial remodelling, we evaluated how lumen area or arterial size changed with accumulating atherosclerotic plaques compared to before plaque development. The original lumen area before plaque development was calculated using the diameter-length relationship. Wall shear stress change ratio was calculated from changes in arterial size.Results Using the old analytical method (and as seen in similar human studies), lumen area increased up to a level of 29% of cross-sectional narrowing. However, with the improved analysis, in cross-sectioning narrowing at levels below 10%, the lumen area modestly decreased, and when the cross-sectional narrowing ranged from 10-68%, the lumen area remained constant, and diminished sharply despite continued remodelling when cross-sectional narrowing reached 70% or above. Arterial remodelling progressed quantitatively to a slight increase in arterial wall shear stress as well as lumen area up to a level of 70% cross-sectional narrowing.Conclusions These findings demonstrate marked influences of arterial tapering and individual variation of arterial size on quantitative analysis of arterial remodelling, and provide the novel insight that coronary compensatory remodelling in atherosclerosis maintains the lumen size up to levels of 70% cross-sectional narrowing in proportion to wall shear stress. (C) 2004 Lippincott Williams Wilkins.