Obstructive sleep apnea and metabolic bone disease: insights into the relationship between bone and sleep.
Obstructive sleep apnea and metabolic bone disease: insights into the relationship between bone and sleep.
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DOI：
10.1002/jbmr.2446
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发表时间：
2015-02
期刊：
影响因子：
--
通讯作者：
Orwoll ES
中科院分区：
文献类型：
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作者：
Swanson CM;Shea SA;Stone KL;Cauley JA;Rosen CJ;Redline S;Karsenty G;Orwoll ES
阻塞性睡眠呼吸暂停（OSA）和低骨量是两种普遍的疾病，特别是在老年人中，这是美国人口的一部分，预计在未来几年将急剧增长。OSA是最常见的睡眠呼吸障碍形式，与多种心血管、代谢、激素和炎症紊乱有关，并可能对骨骼产生不良影响。然而，人们对OSA（包括相关的缺氧和睡眠不足）如何影响骨代谢知之甚少。为了深入了解睡眠和骨之间的关系，我们回顾了越来越多的信息OSA和代谢性骨病，并讨论了病理生理机制，OSA可能会影响骨代谢/架构。
Obstructive sleep apnea (OSA) and low bone mass are two prevalent conditions, particularly among older adults, a section of the U.S. population that is expected to grow dramatically over the coming years. OSA, the most common form of sleep disordered breathing, has been linked to multiple cardiovascular, metabolic, hormonal and inflammatory derangements and may have adverse effects on bone. However, little is known about how OSA (including the associated hypoxia and sleep loss) affects bone metabolism. In order to gain insight into the relationship between sleep and bone, we review the growing information on OSA and metabolic bone disease and discuss the pathophysiological mechanisms by which OSA may affect bone metabolism/architecture.