Histopathological characterization of cholecystectomy specimens in patients with inflammatory bowel disease.
Histopathological characterization of cholecystectomy specimens in patients with inflammatory bowel disease.
复制标题
炎症性肠病患者胆囊切除标本的组织病理学特征。
DOI：
10.1016/j.crohns.2012.02.002
复制
发表时间：
2012
期刊：
影响因子：
--
通讯作者：
J. Goldblum
中科院分区：
文献类型：
--
作者：
Jingmei Lin;B. Shen;H. Lee;J. Goldblum
背景和目的：炎症性肠病与胆石症风险增加有关。然而，胆囊的组织学模式尚未得到广泛研究。本研究旨在描述炎症性肠病患者胆囊切除术标本的组织病理学特征，与对照组相比：78例克罗恩病患者和50例溃疡性结肠炎患者的胆囊切除术标本进行了审查。这些病例与93例年龄和性别相近的非炎症性肠病患者的胆囊切除术进行了比较。结果：溃疡性结肠炎组和克罗恩病组胆囊炎的发生率分别为12%（P< 0.05）和10.3%（P> 0.05），而非炎症性肠病组胆囊炎的发生率仅为4.3%。8%的溃疡性结肠炎患者（P< 0.05）和2.6%的克罗恩病患者（P> 0.05）有急性浆膜炎，而非炎症性肠病对照组为0%。第三种炎症模式，结节性淋巴聚集体，在调整胆石症的影响后，克罗恩病患者显著增加。结节性淋巴聚集体在克罗恩病患者和溃疡性结肠炎患者中的检出率分别为21.2%和9.7%，而在非炎症性肠病对照组中的检出率为5%，克罗恩病组和对照组之间存在显著性差异（P< 0.05）。然而，溃疡性结肠炎患者中更常见的两种炎症模式是明显的慢性胆囊炎和急性浆膜炎，而结节性淋巴聚集体在克罗恩病患者中更常见。
Background and aims:Inflammatory bowel disease is associated with increased risk of cholelithiasis. However, the histologic patterns in gallbladders have not been extensively studied. This study is designed to characterize the histopathologic features of cholecystectomy specimens in inflammatory bowel disease patients, compared to a control group.Methods:Cholecystectomy specimens in 78 Crohn's disease patients and 50 ulcerative colitis patients were reviewed. These were compared with 93 cholecystomies from noninflammatory bowel disease patients of approximate age and sex. The pattern and extent of inflammation was noted.Results:Marked chronic cholecystitis was present in 12% of ulcerative colitis patients (P< 0.05) and 10.3% of Crohn's disease patients (P> 0.05), compared to 4.3% of the noninflammatory bowel disease control group. Eight percent of ulcerative colitis patients (P< 0.05) and 2.6% of Crohn's disease patients (P> 0.05) had acute serositis, compared to 0% of the noninflammatory bowel disease control. The third inflammatory pattern, nodular lymphoid aggregates, was significantly increased in Crohn's disease patients after adjusting for the effect of cholelithiasis. Nodular lymphoid aggregates were found in 21.2% of Crohn's disease patients and 9.7% of ulcerative colitis patients without cholelithiasis, compared to 5% of noninflammatory bowel disease controls without cholelithiasis, a statistically significant difference between the Crohn's disease and control groups (P< 0.05).Conclusions:Inflammatory bowel disease patients show similar inflammatory patterns in cholecystectomy specimens compared to the general population. However, two inflammatory patterns that occur more often in ulcerative colitis patients are marked chronic cholecystitis and acute serositis, while nodular lymphoid aggregates are more common in Crohn's disease patients.