Cellular organization in lab-evolved and extant multicellular species obeys a maximum entropy law.
Cellular organization in lab-evolved and extant multicellular species obeys a maximum entropy law.
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DOI：
10.7554/elife.72707
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发表时间：
2022-02-21
期刊：
影响因子：
7.7
通讯作者：
Yunker PJ
中科院分区：
文献类型：
--
作者：
Day TC;Höhn SS;Zamani-Dahaj SA;Yanni D;Burnetti A;Pentz J;Honerkamp-Smith AR;Wioland H;Sleath HR;Ratcliff WC;Goldstein RE;Yunker PJ
多细胞生物的流行部分是由于它们形成复杂结构的能力。细胞如何在这些结构中包装是一个基本的生物物理问题，是它们功能特性的基础。然而，关于细胞堆积几何形状如何产生，以及它们如何受到生长过程中随机噪声的影响-特别是缺乏发育程序-仍然有很多未知数。在这里，我们量化的两个不同的多细胞真核生物：实验室进化的'雪花'酵母和绿色团藻carteri的细胞邻域的统计。我们发现，尽管在细胞组织中存在很大差异，但与两种生物体中的单个细胞相关的自由空间非常适合修改后的伽马分布，与最初为颗粒状材料开发的最大熵预测一致。这种“熵”的细胞包装确保了一定程度的可预测性，尽管噪音，促进父母后代的忠诚，即使在没有发育调节。再加上不同的生长形态的模拟，这些结果表明，伽马分布的细胞邻域大小是多细胞的一个一般特征，从保守的统计细胞包装。
The prevalence of multicellular organisms is due in part to their ability to form complex structures. How cells pack in these structures is a fundamental biophysical issue, underlying their functional properties. However, much remains unknown about how cell packing geometries arise, and how they are affected by random noise during growth - especially absent developmental programs. Here, we quantify the statistics of cellular neighborhoods of two different multicellular eukaryotes: lab-evolved ‘snowflake’ yeast and the green alga Volvox carteri. We find that despite large differences in cellular organization, the free space associated with individual cells in both organisms closely fits a modified gamma distribution, consistent with maximum entropy predictions originally developed for granular materials. This ‘entropic’ cellular packing ensures a degree of predictability despite noise, facilitating parent-offspring fidelity even in the absence of developmental regulation. Together with simulations of diverse growth morphologies, these results suggest that gamma-distributed cell neighborhood sizes are a general feature of multicellularity, arising from conserved statistics of cellular packing.