A Closed-Loop Control Strategy for Glucose Control in Artificial Pancreas Systems
A Closed-Loop Control Strategy for Glucose Control in Artificial Pancreas Systems
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DOI：
10.1109/ised.2012.76
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发表时间：
2012-12
期刊：
影响因子：
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通讯作者：
Jamil Galadanci;R. Shafik;J. Mathew;A. Acharyya;D. Pradhan
中科院分区：
文献类型：
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作者：
Jamil Galadanci;R. Shafik;J. Mathew;A. Acharyya;D. Pradhan
维持良好的血糖控制是1型糖尿病患者的持续挑战。目前的胰岛素治疗手段被认为会使患者发生高血糖和低血糖发作。随着计算机科学和技术的进步，提出了人工胰腺，一种通过提供健康胰腺的胰岛素供应功能的替代物来自动控制患者的血糖水平的计算机化装置。该设备的开发所面临的主要挑战是全闭环控制系统。在本文中，我们提出了一个人工胰腺系统的自适应闭环控制策略，计算适当的胰岛素输注速率，从而保持患者的血糖浓度在正常血糖范围内。通过严格的模式识别技术实现自适应性，在给定的采样步骤通过葡萄糖监测仪获得患者特定的葡萄糖读数。控制策略的性能进行评估，使用各种生理干扰和膳食摄入下进行的仿真结果。
Maintaining good glycemic control is a continuous challenge for type-1 diabetic patients. The current means of insulin therapy are seen to subject patients to hyper- and hypoglycemic episodes. With the advancement of computer science and technology, an artificial pancreas, a computerized device that will automatically control patient's blood glucose level by providing the substitute for the insulin supply functionality of a healthy pancreas was proposed. The main challenge faced by the development of this device is a fully closed-loop control system. In this paper we proposed an artificial pancreas system with an adaptive closed-loop control strategy that computes the appropriate insulin infusion rate and thereby keeping the patient's blood glucose concentration within normoglycemic range. The adaptability is achieved through a rigorous pattern recognition technique with patient-specific glucose readings obtained through glucose monitor at a given sampling step. The performance of the control strategy is assessed using the simulation results carried out under various physiological disturbances and meal intake.