The effect of ischaemia on the excitability of sensory nerves in diabetes mellitus.
The effect of ischaemia on the excitability of sensory nerves in diabetes mellitus.
复制标题
缺血对糖尿病感觉神经兴奋性的影响。
DOI：
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复制
发表时间：
1968
影响因子：
11
通讯作者：
O. Peiris
中科院分区：
文献类型：
--
作者：
K. Seneviratne;O. Peiris
A reduction of the conduction velocity in the motor nerves of diabetic patients has been shown by Mulder, Lambert, Bastron, and Sprague (1961), Skillman, Johnson, Hamwi, and Driskill (1961), and Lawrence and Locke (1961). They found evidence of slowing of the conduction velocity in patients who had evidence of a clinical neuropathy, and by statistical comparison demonstrated a reduced conduction velocity in some of their diabetic subjects who had no clinical evidence of a neuropathy. Downie and Newell (1961) and Gilliatt and Willison (1962), using evoked potential techniques, have demonstrated an absence or a diminution of the sensory nerve action potential with a slowing of the distal conduction velocity in diabetics. A reduction of the conduction velocity was however not a constant feature in all diabetics, for Lawrence and Locke (1961) and Skillman et al. (1961) have observed conduction velocities as fast or faster than the mean values for controls in several of their diabetic subjects who had clinical evidence of a peripheral neuropathy. Poole (1956a) has shown that ischaemic and postischaemic paraesthesiae occur very constantly in healthy subjects between the ages of 12 to 60 years, when the circulation in the upper limb is restored after it has been occluded for a certain minimum duration. Poole (1956b) also showed that these paraesthesiae were absent or diminished in intensity or duration in subjects who had evidence of peripheral sensory nerve disease. In this study, excitability changes in relation to ischaemia in the sensory nerves of patients with diabetes mellitus have been investigated. We have in the accompanying paper (Seneviratne and Peiris, 1968) shown that there is a good correlation between these excitability changes and the times of onset and duration of ischaemic and post-ischaemic paraesthesiae.
