Effects of alcohol feeding on androgen receptors in the rat pituitary gland.
Effects of alcohol feeding on androgen receptors in the rat pituitary gland.
复制标题
酒精喂养对大鼠垂体雄激素受体的影响。
DOI：
10.1016/0024-3205(87)90483-8
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发表时间：
1987
期刊：
影响因子：
6.1
通讯作者：
K. Chung
中科院分区：
文献类型：
--
作者：
K. Chung
Specific binding of testosterone-1β, 2β-3H by cytosol from anterior pituitary gland of alcohol-fed, isocaloric control, and castrated control and alcohol-fed rats with or without testosterone treatment has been investigated by charcoal assay. The number of androgen binding sites was significantly reduced in alcohol-fed rats (8±1.0 fmoles/mg cytosol protein), when compared to the isocaloric control value (13.2±2.1 fmoles/mg protein), with no significant change in Kd (0.7±0.14 nM). Castration significantly increased the number of receptor sites in control rats and when castrated control animals were treated with testosterone the binding sites were decreased to the intact control level. In contrast, castration or testosterone given to castrated alcohol-fed rats did not alter alcohol-induced reduction of the receptor sites. The binding affinity (Kd) is identical in all groups. The concentration of serum luteinizing hormone (LH) was significantly lower in alcohol-fed rats when compared to that of normal controls. An increased serum LH level with a decreased testosterone level was noted in castrated control rats. However, castration of alcohol-fed rats had little or no effects on the concentrations of LH and testosterone. Administration of testosterone suppressed castration-induced high LH in control rats but alcohol-induced reduction of LH level was not altered by this treatment. These findings indicate that alcohol exerts a suppressive effect on the content of androgen receptors and secretory functions of gonadotropins in the pituitary gland.
检查乙醇引起的睾丸损伤的各种机制：利用分离的灌注大鼠睾丸进行研究。
影响因子：
4.8
作者：
VanThiel,DH;Cobb,CF;Herman,GB;Perez,HA;Estes,L;Gavaler,JS
通讯作者：
Gavaler,JS
影响因子：
3.6
作者：
HANDA, RJ;REID, DL;RESKO, JA
通讯作者：
RESKO, JA