Serum vitamin D and subsequent occurrence of type 2 diabetes
Serum vitamin D and subsequent occurrence of type 2 diabetes
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DOI：
10.1097/ede.0b013e318176b8ad
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发表时间：
2008-09-01
期刊：
影响因子：
5.4
通讯作者：
Reunanen, Antti
中科院分区：
文献类型：
--
作者：
Knekt, Paul;Laaksonen, Maarit;Reunanen, Antti
背景：低维生素D水平已被认为是2型糖尿病的危险因素。尽管表皮病学证据很少，但最近的两项研究表明两者存在关联。本研究探讨了血清维生素D与2型糖尿病发病率的关系，使用汇总数据从这2 cohols.Methods：两个巢式病例对照研究，收集的芬兰移动的诊所在1973-1980年，汇总分析。研究人群包括年龄40-74岁且基线时无糖尿病的男性和女性。在22年的随访期间，发生了412例2型糖尿病病例，并通过个体匹配选择了986例对照。血清维生素D（血清25（OH）D）从冷冻样本中测定，储存在基线。汇总估计血清维生素D浓度和2型糖尿病发病率之间的关系calculated.Results：男性有较高的血清维生素D浓度比女性，并显示在他们的最高维生素D四分位数的2型糖尿病的风险降低。调整吸烟、体重指数、体力活动和教育程度后，男性和女性的最高和最低四分位数之间的相对优势分别为0.28（95%，置信区间= 0.10-0.811）和1.14（0.60-2.17）。残留混杂因素可能促成了这种关联。
Background: Low vitamin D status has been suggested as a risk factor for type 2 diabetes. Although the epidermiologic evidence is scarce, 2 recent studies have suggested an association. The present study investigated the relation of serum vitamin D with type 2 diabetes incidence using pooled data from these 2 cohorts.Methods: Two nested case-control Studies, collected by the Finnish Mobile Clinic in 1973-1980, were pooled for analysis. The study Populations consisted of men and women aged 40-74 years and free of diabetes at baseline. During a follow-up period of 22 years, 412 incident type 2 diabetes cases occurred, and 986 controls were selected by individual matching. Serum vitamin D (serum 25(OH)D)was determined from frozen samples, stored at baseline. Pooled estimates of the relationship between serum vitamin D concentration and type 2 diabetes incidence were calculated.Results: Men had higher serum vitamin D concentrations than women and showed a reduced risk of type 2 diabetes in their highest vitamin D quartile. The relative odds between the highest and lowest quartiles was 0.28 (95%, confidence interval = 0.10-0.811) in men and 1.14 (0.60-2.17) in women after adjustment for smoking, body mass index, physical activity, and education.Conclusions: The results support the hypothesis that high vitamin D status provides protection against type 2 diabetes. Residual confounding may contribute to this association.