Effect of family cohesion on symptom distress during hematopoietic stem cell transplantation.
Effect of family cohesion on symptom distress during hematopoietic stem cell transplantation.
复制标题
家庭凝聚力对造血干细胞移植期间症状困扰的影响。
DOI：
10.1007/s00520-021-06593-z
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
VonAh,Diane
中科院分区：
文献类型：
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作者：
Yang,Yesol;Pan,Wei;Farag,SherifS;VonAh,Diane
目的家庭在造血干细胞移植（HSCT）后的恢复过程中可能发挥重要作用，但家庭功能对个体健康的影响却知之甚少。本研究的目的是探讨影响的家庭凝聚力（家庭功能）的轨迹HSCT收件人的症状困扰（症状频率和症状困扰）之前，期间和之后HSCT.MethodsSecondary分析进行了使用收集的数据从178个人接受HSCT。纵向平行过程（LPP）建模研究如何家庭凝聚力和造血干细胞相关的症状（症状频率和症状困扰）随时间的变化，以及这些纵向变化如何相互关联。在基线（T1）时经历较高家庭亲密度的HSCT受者在T1时表现出较低的症状频率（p< .01）以及症状困扰（p< .01）。这一轨迹分析还表明，HSCT收件人谁提高了家庭凝聚力随着时间的推移报告减少症状频率（p<0.01），以及麻烦（p<0.01）随着时间的推移。旨在增强家庭凝聚力的干预措施有可能降低HSCT接受者的症状困扰。需要进一步的研究来了解家庭凝聚力和家庭功能的关键作用，以及它们与HSCT症状困扰预防，早期发现和风险分层的关系。
PurposeFamily may play an important role in hematopoietic stem cell transplantation (HSCT) recovery; however, little is known about the effect of family functioning on an individual’s health. The purpose of this study was to examine the effect of family cohesion (family functioning) on the trajectory of HSCT recipients’ symptom distress (symptom frequency and symptom bother) before, during, and after HSCT.MethodsSecondary analysis was conducted using data collected from178 individuals who underwent HSCT. Longitudinal parallel process (LPP) modeling was used to examine how family cohesion and HSCT-associated symptoms (symptom frequency and symptom bother) change over time, and how these longitudinal changes relate to each other.ResultsThe trajectory of family cohesion predicted the trajectories of HSCT-associated symptom frequency and bother. HSCT recipients who experienced higher family cohesion at baseline (T1) showed lower symptom frequency (p< .01) as well as symptom bother (p< .01) at T1. This trajectory analysis also showed that HSCT recipients who had improved family cohesion over time reported decrease in symptom frequency (p< .01) as well as bother (p< .01) over time.ConclusionFindings indicate that higher family cohesion predicts decrease in symptom distress over the HSCT trajectory. Interventions aimed at enhancing family cohesion have the potential to lower HSCT recipients’ symptom distress. Further research is needed to understand the critical role of family cohesion and family functioning and their relationship with HSCT symptom distress prevention, early detection, and risk stratification.