A GABAergic component in the commissure of the inferior colliculus in rat
A GABAergic component in the commissure of the inferior colliculus in rat
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DOI：
10.1097/01.wnr.0000236857.70715.be
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发表时间：
2006-10-23
期刊：
影响因子：
1.7
通讯作者：
Malmierca, Manuel S.
中科院分区：
文献类型：
--
作者：
Hernandez, Olga;Rees, Adrian;Malmierca, Manuel S.
下丘连合是皮层下水平听觉通路两侧同源结构之间连接的终点。兴奋性纤维的存在是公认的，但抑制成分的存在是有争议的。使用大鼠，我们将生物素化的葡聚糖胺注射到一侧的下丘中，以逆行标记从对侧下丘通过连合突出的细胞。免疫细胞化学的γ-氨基-N-丁酸在相邻的半薄切片显示，20%的生物素化葡聚糖胺细胞配置文件也标记为γ-氨基-N-丁酸。我们的结论是，单突触抑制性连接有助于抑制在对侧下丘的连合投射的功能研究。
The commissure of the inferior colliculus is significant as the final point of interconnection between homologous structures on the two sides of the auditory pathway at the subcortical level. The presence of excitatory fibres is well established in this tract, but the existence of an inhibitory component is controversial. Using rats, we injected biotinylated dextran amine into the inferior colliculus on one side to retrogradely label cells projecting through the commissure from the contralateral inferior colliculus. Immunocytochemistry for gamma-amino-n-butyric acid in neighbouring semithin sections revealed that 20% of biotinylated dextran amine cell profiles were also labelled for gamma-amino-n-butyric acid. We conclude that monosynaptic inhibitory connections contribute to the inhibition observed in the contralateral inferior colliculus in functional studies of the commissural projection.