The effects of alcohol consumption on flow-mediated dilation in humans: A systematic review.
The effects of alcohol consumption on flow-mediated dilation in humans: A systematic review.
复制标题
DOI：
10.14814/phy2.14872
复制
发表时间：
2021-05
影响因子：
2.5
通讯作者：
Phillips SA
中科院分区：
文献类型：
--
作者：
Hwang CL;Piano MR;Phillips SA
内皮功能的变化可能有助于酒精消费对心血管疾病（如高血压和冠状动脉疾病）的积极和消极影响。许多研究使用肱动脉血流介导的扩张（FMD）来检查饮酒对人类内皮功能的影响。然而，这些发现并不一致，可能是由于多种因素，如受试者特征的异质性、饮酒模式和饮酒量/剂量。因此，本系统性综述的目的是考虑上述因素，研究饮酒对人类肱动脉FMD的影响。该综述发现，虽然轻度至中度饮酒对FMD的影响可能很小，但重度饮酒与FMD的减少有关。然而，大多数已发表的研究包括健康，年轻和男性个体，限制了对其他人群的普遍性。未来的研究应该包括更多的女性，老年人，以及来自不同背景和代表性不足的人。许多研究使用肱FMD来检查饮酒对内皮功能的影响，但结果不一致。这可能是由于多种因素，如受试者特征的异质性（疾病与健康）、酒精类型和量以及测量时间（急性与慢性消耗）。因此，本系统性综述的目的是研究饮酒对人类FMD的影响。
Changes in endothelial function may contribute to the positive and negative effects of alcohol consumption on cardiovascular conditions, such as hypertension and coronary artery disease. Numerous studies have used brachial artery flow‐mediated dilation (FMD) to examine the effects of alcohol consumption on endothelial function in humans. However, the findings are inconsistent and may be due to multiple factors such as heterogeneity in subject characteristics, the alcohol use pattern, and amount/dose of alcohol consumed. Therefore, the aim of this systematic review was to investigate the effect of alcohol consumption on brachial artery FMD in humans considering the above‐mentioned factors. This review found that while light to moderate alcohol consumption may have minimal effects on FMD, heavy alcohol consumption was associated with a decrease in FMD. However, most of the published studies included healthy, younger, and male individuals, limiting generalizability to other populations. Future studies should include more women, older subjects, and those from diverse and underrepresented backgrounds. Numerous studies have used brachial FMD to examine the effects of alcohol consumption on endothelial function, but the findings are inconsistent. This may be due to multiple factors such as heterogeneity in subject characteristics (disease vs. healthy), alcohol type and amount, and measurement timing (acute vs. chronic consumption). Therefore, the purpose of this systematic review was to investigate the effect of alcohol consumption on FMD in human.