BMI-1, a promising therapeutic target for human cancer (Review)
BMI-1, a promising therapeutic target for human cancer (Review)
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DOI：
10.3892/ol.2015.3361
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发表时间：
2015-08-01
期刊：
影响因子：
2.9
通讯作者：
Nan, Ke-Jun
中科院分区：
文献类型：
--
作者：
Wang, Min-Cong;Li, Chun-Li;Nan, Ke-Jun
BMI-1癌基因属于多梳组基因家族，是一种转录抑制因子。BMI-1的过表达已在多种人类癌症组织中被鉴定，并且已知其参与癌细胞增殖、细胞侵袭、远处转移、化学敏感性和患者存活。越来越多的证据表明，BMI-1还参与调节癌症干细胞（CSC）的自我更新、分化和肿瘤起始。然而，这些生物学过程的分子机制仍不清楚。本文综述了BMI-1在不同肿瘤类型和肿瘤干细胞中的作用，并探讨了BMI-1可能参与的信号通路。总之，BMI-1可能是预防和治疗各种癌症的一个有前途的靶点。
BMI-1 oncogene is a member of the polycomb-group gene family and a transcriptional repressor. Overexpression of BMI-1 has been identified in various human cancer tissues and is known to be involved in cancer cell proliferation, cell invasion, distant metastasis, chemosensitivity and patient survival. Accumulating evidence has revealed that BMI-1 is also involved in the regulation of self-renewal, differentiation and tumor initiation of cancer stem cells (CSCs). However, the molecular mechanisms underlying these biological processes remain unclear. The present review summarized the function of BMI-1 in different human cancer types and CSCs, and discussed the signaling pathways in which BMI-1 is potentially involved. In conclusion, BMI-1 may represent a promising target for the prevention and therapy of various cancer types.