Milk makes lysosomes lethal.
Milk makes lysosomes lethal.
复制标题
牛奶使溶酶体致命。
DOI：
10.1038/ncb3059
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发表时间：
2014
影响因子：
21.3
通讯作者：
Krishna S
中科院分区：
文献类型：
--
作者：
Krishna S
在哺乳期后乳腺退化过程中，Stat3已被证明在体内调节溶酶体膜透化和细胞死亡。现在揭示，Stat3通过引起乳脂球的吞噬作用诱导溶酶体膜透化，这使溶酶体膜不稳定，导致组织蛋白酶蛋白酶的泄漏。
Stat3 has been shown to regulate lysosome membrane permeabilization and cell deathin vivoduring post-lactation mammary gland involution. It is now revealed that Stat3 induces lysosome membrane permeabilization by causing phagocytosis of milk fat globules, which destabilize the lysosome membrane leading to leakage of cathepsin proteases.