NEURAL CORRELATES OF DISGUST- AND FEAR-CONDITIONED RESPONSES
NEURAL CORRELATES OF DISGUST- AND FEAR-CONDITIONED RESPONSES
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DOI：
10.1016/j.neuroscience.2011.11.007
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发表时间：
2012-01-10
期刊：
影响因子：
3.3
通讯作者：
Stark, R.
中科院分区：
文献类型：
--
作者：
Klucken, T.;Schweckendiek, J.;Stark, R.
了解恶心刺激反应的个体差异对于更深入地了解某些精神疾病的发展非常重要。本研究的目的是探讨条件性厌恶反应，其潜在的重叠与条件性恐惧反应（CR）和厌恶敏感性的影响，血氧水平依赖性反应。然而，即使目前的研究报告证据表明，厌恶敏感性是一个脆弱的因素，知识的基础神经机制仍然非常有限。两组人分别接受厌恶条件反射和恐惧条件反射。使用功能性磁共振成像，我们确定了一个联合激活网络，包括扣带皮层，核丘脑，眶额皮层，枕叶皮层内的厌恶和恐惧条件反射组。此外，我们报告的证据表明，在厌恶条件反射组中，神经元激活增加。此外，功能连接性分析显示，与低厌恶敏感性组相比，高厌恶敏感性组的神经元之间的相互联系增加了。联合结果表明，厌恶和恐惧条件反射的条件反应招募相同的神经网络，这意味着厌恶学习的不同条件反应依赖于一个共同的神经网络。厌恶条件反射组中脑岛激活的增加可能归因于内感受过程的增强，这在厌恶中可能更加明显。最后，关于厌恶敏感性的研究结果进行了讨论，就某些精神疾病的脆弱性因素。皇冠版权所有（C）2011由爱思唯尔有限公司代表IBRO发布。All rights reserved.
The understanding of individual differences in responses to disgusting stimuli is important to gain more insight into the development of certain psychiatric disorders. The aim of this study was to investigate conditioned disgust responses, its potential overlap with conditioned fear responses (CRs) and the influence of disgust sensitivity on blood oxygen level dependent responses. Yet even though current studies report evidence that disgust sensitivity is a vulnerability factor, the knowledge about the underlying neural mechanisms remains very limited. Two groups were exposed either to a disgust- or a fear-conditioning paradigm. Using functional magnetic resonance imaging, we identified a conjoint activated network including the cingulate cortex, the nucleus accumbens, the orbitofrontal cortex, and the occipital cortex within the disgust- and the fear-conditioning group. Moreover, we report evidence of increased insula activation in the disgust-conditioning group. In addition, functional connectivity analysis revealed increased interconnections, most pronounced within the insula in the high disgust sensitivity group compared with the low disgust sensitivity group. The conjunction results suggest that the conditioned responses in disgust and fear conditioning recruit the same neural network, implicating that different conditioned responses of aversive learning depend on a common neural network. Increased insula activation within the disgust-conditioning group might be attributable to heightened interoceptive processes, which might be more pronounced in disgust. Finally, the findings regarding disgust sensitivity are discussed with respect to vulnerability factors for certain psychiatric disorders. Crown Copyright (C) 2011 Published by Elsevier Ltd on behalf of IBRO. All rights reserved.