Current Status and Practical Use of Effluent Biomarkers in Peritoneal Dialysis Patients
Current Status and Practical Use of Effluent Biomarkers in Peritoneal Dialysis Patients
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DOI：
10.1053/j.ajkd.2013.01.031
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发表时间：
2013-10-01
影响因子：
13.2
通讯作者：
Krediet, Raymond T.
中科院分区：
文献类型：
--
作者：
Barreto, Deirisa Lopes;Krediet, Raymond T.
长期腹膜透析治疗可导致腹膜功能和形态的改变。腹膜透析膜的评估通常是通过研究小溶质和液体的运输来完成的。评估形态学改变及其发展需要反复的腹膜活检，这通常是不可行的。在腹膜透析期间，腹膜组织浸泡在透析溶液中，并可能分泌或脱落可在腹膜流出物中回收的物质。这些分子流出物生物标志物可能有助于了解形态学变化。在这篇综述中，建立和新兴的候选生物标志物腹膜透析进行了讨论。此外，对腹膜透析出水生物标志物的要求、挑战和临床应用进行了讨论。中华肾脏病杂志，2014(4):823-833。(C) 2013年由国家肾脏基金会，Inc。
Long-term peritoneal dialysis therapy can lead to alterations in the function and morphology of the peritoneal membrane. Assessment of the peritoneal dialysis membrane usually is done by investigating the transport of small solutes and fluid. Assessment of morphologic alterations and their development would require repetitive peritoneal biopsies that usually are not feasible. Peritoneal tissues are bathed in dialysis solutions during peritoneal dialysis and may secrete or shed substances that can be recovered in peritoneal effluent. These molecular effluent biomarkers may give insight into morphologic changes. In this review, established and emerging candidate biomarkers in peritoneal dialysis are discussed. Additionally, requirements, challenges, and clinical applications of effluent biomarkers in peritoneal dialysis are addressed. Am J Kidney Dis. 62(4):823-833. (C) 2013 by the National Kidney Foundation, Inc.