Podoplanin (D2-40) is a novel marker for follicular dendritic cell tumors
Podoplanin (D2-40) is a novel marker for follicular dendritic cell tumors
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DOI：
10.1309/7p8u659jbjcv6eeu
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发表时间：
2007-11-01
影响因子：
3.5
通讯作者：
Hornick, Jason L.
中科院分区：
文献类型：
--
作者：
Yu, Hongbo;Gibson, Joanna A.;Hornick, Jason L.
由单克隆抗体D2-40识别的Podoplanin可能是滤泡树突状细胞（FDC）肿瘤的有用标志物。研究了125例树突状细胞、组织细胞和梭形细胞病变的石蜡切片，包括11 FDC肿瘤，5例叉指状树突状细胞肿瘤，10例组织细胞肉瘤，5例朗格汉斯细胞组织细胞增生症，5例窦组织细胞增生症伴巨大淋巴结病，5例淋巴结或脾脏炎性假瘤，9例结节卡波西肉瘤，6例炎性肌纤维母细胞瘤（IMT），29例胃肠道间质瘤（GIST）、恶性外周神经鞘瘤、平滑肌肉瘤、单相滑膜肉瘤（SS）和孤立性纤维瘤各10例。Podoplanin仅在其他肿瘤类型中偶尔观察到表达，包括7例GIST（24%），2例IMT（33%）和3例SS（30%），并且通常较弱且为胞浆型。对podoplanin的反应性在梭形细胞GIST（5113 [38%]）中比在上皮样或混合型GIST（2116 [13%1]）中更常见。Podoplanin是FDC肿瘤的一种高度敏感的标记物，与常规FDC标记物联合可能有助于确诊，特别是在树突状细胞和组织细胞病变的鉴别诊断中。
Podoplanin, recognized by monoclonal antibody D2-40, may be a useful marker for follicular dendritic cell (FDC) tumors. Paraffin sections of 125 dendritic cell, histiocytic, and spindle cell lesions were studied, including I I FDC tumors, 5 interdigitating dendritic cell tumors, 10 histiocytic sarcomas, 5 Langerhans cell histiocytosis, 5 sinus histiocytosis with massive lymphadenopathy, 5 inflammatory pseudotumors of lymph node or spleen, 9 nodal Kaposi sarcomas, 6 inflammatory myofibroblastic tumors (IMTs), 29 gastrointestinal stromal tumors (GISTs), and 10 cases each of malignant peripheral nerve sheath tumor, leiomyosarcoma, monophasic synovial sarcoma (SS), and solitary fibrous tumor All FDC tumors and Kaposi sarcomas showed strong inummoreactivity for podoplanin (predominantly membranous). Podoplanin expression was only occasionally observed in the other tumor types, including 7 GISTs (24%), 2 IMTs (33%), and 3 SS (30%), and was generally weak and cytoplasmic. Reactivity for podoplanin was more common in spindle cell GISTs (5113 [38%]) than in epithelioid or mixed-type GISTs (2116 [13%1). Podoplanin is a highly sensitive markerfor FDC tumors and may be useful to help confirm the diagnosi's in conjunction with conventional FDC markers, particularly in the differential diagnosis of dendritic cell and histiocytic lesions.