Engineering Large Animal Species to Model Human Diseases.
Engineering Large Animal Species to Model Human Diseases.
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DOI：
10.1002/cphg.18
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发表时间：
2016-07-01
影响因子：
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通讯作者：
Rogers CS
中科院分区：
文献类型：
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作者：
Rogers CS
动物模型是研究人类疾病的重要资源。基因工程小鼠是最常用的物种，为我们理解基础生物学、疾病机制和药物开发做出了重大贡献。然而，它们往往无法重现人类疾病的重要方面，因此作为转化研究工具的实用性有限。在与人类更相似的物种中开发疾病模型可能为研究疾病发病机制和测试新疗法提供更好的环境。本单元概述了基因工程大型动物的历史以及使其发展成为可能的技术。还涵盖了在规划大型动物模型时需要考虑的因素，包括物种的选择、修饰类型和方法、表征、生产方法和法规遵从性。
Animal models are an important resource for studying human diseases. Genetically engineered mice are the most commonly used species and have made significant contributions to our understanding of basic biology, disease mechanisms, and drug development. However, they often fail to recreate important aspects of human diseases and thus can have limited utility as translational research tools. Developing disease models in species more similar to humans may provide a better setting in which to study disease pathogenesis and test new treatments. This unit provides an overview of the history of genetically engineered large animals and the techniques that have made their development possible. Factors to consider when planning a large animal model, including choice of species, type of modification and methodology, characterization, production methods, and regulatory compliance are also covered.