Aging, self-referencing, and medial prefrontal cortex
Aging, self-referencing, and medial prefrontal cortex
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DOI：
10.1080/17470910701399029
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发表时间：
2007-06-01
影响因子：
2
通讯作者：
Schacter, Daniel L.
中科院分区：
文献类型：
--
作者：
Gutchess, Angela H.;Kensinger, Elizabeth A.;Schacter, Daniel L.
随着健康老龄化，外侧前额叶皮质在结构和功能上都会发生变化。相比之下，内侧前额叶皮质的结构变化较小，但对于该区域随年龄增长而发生的功能变化知之甚少。我们采用事件相关的功能性磁共振成像设计，研究了自我参照过程中内侧前额叶皮质的反应，以便在年轻人和老年人表现相似且已知该任务能使年轻人的该区域积极参与的任务上对不同年龄组进行比较。19名年轻人（平均年龄 = 23岁）和17名老年人（平均年龄 = 72岁）判断形容词是描述自己、他人，还是以大写形式呈现。我们评估了年轻人和老年人在自我参照效应（自我与他人）方面激活的重叠情况，发现两组在自我参照时都涉及内侧前额叶皮质和中扣带回。在自我与他人的人格评估中，两组之间唯一的大脑差异出现在躯体感觉和运动相关区域。相比之下，在用于情绪效价处理的大脑网络中发现了与年龄相关的调节。老年人（而非年轻人）在处理积极项目相对于消极项目时，背外侧前额叶皮质的活动增加，这可能反映了老年人对积极信息的控制性加工增加。
The lateral prefrontal cortex undergoes both structural and functional changes with healthy aging. In contrast, there is little structural change in the medial prefrontal cortex, but relatively little is known about the functional changes to this region with age. Using an event-related fMRI design, we investigated the response of medial prefrontal cortex during self-referencing in order to compare age groups on a task that young and elderly perform similarly and that is known to actively engage the region in young adults. Nineteen young (M age = 23) and seventeen elderly (M age = 72) judged whether adjectives described themselves, another person, or were presented in upper case. We assessed the overlap in activations between young and elderly for the self-reference effect (self vs. other person), and found that both groups engage medial prefrontal cortex and mid-cingulate during self-referencing. The only cerebral differences between the groups in self versus other personality assessment were found in somatosensory and motor-related areas. In contrast, age-related modulations were found in the cerebral network recruited for emotional valence processing. Elderly (but not young) showed increased activity in the dorsal prefrontal cortex for positive relative to negative items, which could reflect an increase in controlled processing of positive information for elderly adults.