Whole-body insulin sensitivity, low-density lipoprotein (LDL) particle size, and oxidized LDL in overweight, nondiabetic men
Whole-body insulin sensitivity, low-density lipoprotein (LDL) particle size, and oxidized LDL in overweight, nondiabetic men
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DOI：
10.1053/meta.2002.35577
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发表时间：
2002-11-01
影响因子：
9.8
通讯作者：
Melby, CL
中科院分区：
文献类型：
--
作者：
Ho, RC;Davy, K;Melby, CL
胰岛素抵抗通常伴随着血浆甘油三酯（TG）升高和小而致密的低密度脂蛋白（LDL）颗粒的优势。然而，目前尚不清楚胰岛素抵抗是否与LDL颗粒大小有关，而与血浆TG无关。我们试图在一组超重、非糖尿病男性中确定这些变量之间关系的强度[N = 34；体重指数[BIVII] 25 ~ 35 kg/m(2)；年龄（50 ~ 75岁），以及检查胰岛素敏感性与氧化LDL （oxLDL）之间可能的关系。我们还通过基于空腹胰岛素和葡萄糖浓度的计算指数，检验了这些脂质变量与胰岛素敏感性之间的关系强度。胰岛素敏感性（Si）与总TG （r = -0.61, P < .001）、极低密度脂蛋白(VLDL)-TG （r = -0.60, P < .001）和LDL大小（r = .414, P < .05）显著相关。LDL大小与TG （r = -0.73, P < 0.001）、VLDL-TG （r = -0.73, P < 0.001）、高密度脂蛋白-胆固醇（HDL-C） （r = 0.65, P < 0.001）、胰岛素定量敏感性检查指数（QUICKI） （rho = 0.46, P < 0.01）、胰岛素抵抗评估稳态模型（HOMA-IR） （rho = -0.45, P < 0.01）也有显著相关。Si是LDL大小的重要预测因子，年龄和BMI也是LDL大小变化的独立因素（R-2 = 0.172）。然而，当模型中加入TG和HDL-C时，Si不再是LDL大小的显著预测因子。Si与oxLDL的相关性较弱，但具有统计学意义（rho = -0.40, P = 0.02）。这些数据表明，Si和LDL大小之间的关系在很大程度上是由血浆TG介导的，而在超重、非糖尿病男性中，Si与oxLDL的相关性较弱。版权所有，爱思唯尔科学（美国）。版权所有。
Insulin resistance is often accompanied by elevated plasma triglycerides (TG) and a preponderance of small, dense low-density lipoprotein (LDL) particles. However, it remains unclear whether or not insulin resistance is related to LDL particle size, independent of plasma TG. We sought to determine the strength of the relationships among these variables in a group of overweight, nondiabetic men [N = 34; body mass index [BIVII], 25 to 35 kg/m(2); age, 50 to 75 years), as well as to examine the possible relation between insulin sensitivity and oxidized LDL (oxLDL). We also examined the strength of the relationships between these lipid variables and estimates of insulin sensitivity using calculated indices based on fasting insulin and glucose concentrations. Insulin sensitivity (Si) was significantly associated with total TG (r = -0.61, P < .001), very-low-density lipoprotein (VLDL)-TG (r = -0.60, P < .001), and LDL size (r = .414, P < .05). LDL size was also significantly associated with TG (r = -0.73, P < .001), VLDL-TG (r = -0.73, P < .001), high-density lipoprotein-cholesterol (HDL-C) (r = 0.65, P < .001), the quantitative insulin sensitivity check index (QUICKI) (rho = 0.46, P < .01), and the homeostatic model for the assessment of insulin resistance (HOMA-IR) (rho = -0.45, P < .01). Si was a significant predictor of LDL size, with age and BMI also independent contributors to the variance in LDL size (R-2 = 0.172). However, when TG and HDL-C were added to the model, Si was no longer a significant predictor of LDL size. The correlation between Si and oxLDL was weak, but stastically significant (rho = -0.40, P = .02). These data suggest that the relation between Si and LDL size is largely mediated by plasma TG, and that Si is only weakly related to oxLDL in overweight, nondiabetic men. Copyright 2002, Elsevier Science (USA). All rights reserved.