Flow-mediated vasodilation was found to be an independent predictor of changes in the carotid plaque status during a 5-year follow-up.
Flow-mediated vasodilation was found to be an independent predictor of changes in the carotid plaque status during a 5-year follow-up.
复制标题
在 5 年随访期间，发现血流介导的血管舒张是颈动脉斑块状态变化的独立预测因子。
DOI：
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发表时间：
2014
影响因子：
4.4
通讯作者：
L. Lind
中科院分区：
文献类型：
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作者：
L. Lind
目的
先前已经表明，血流介导的血管舒张是内膜中层厚度（IMT）进展的预测因子。在本研究中，阻力动脉和导管动脉中内皮依赖性血管舒张的程度被评估为 IMT 和斑块进展的预测因子。
方法
在乌普萨拉老年人血管系统前瞻性研究 (PIVUS) 试验（1,016 名 70 岁受试者）中，评估了在肱动脉中注射乙酰胆碱的侵入性前臂技术（阻力动脉，EDV）和测量血流介导扩张的肱动脉超声技术（导管动脉，FMD）。在基线调查和五年后的随访中使用超声记录 IMT 和有斑块的颈动脉数量（0、1 或 2）。
结果
在这两项研究中，共有 760 名受试者在 70 岁和 75 岁时进行了 IMT 和颈动脉斑块的有效测量。 FMD 和 EDV 均未显着预测五年内 IMT 的变化。然而，FMD（而非 EDV）与随访期间颈动脉斑块负荷的变化相关，独立于传统危险因素，如性别、腰围、空腹血糖、收缩压和舒张压、HDL 和 LDL 胆固醇、血清甘油三酯、BMI 和吸烟（FMD 1 SD 变化的 OR 为 0.81，95% CI 0.68 至 0.95， p=0.010）。
结论
在 5 年随访期间，发现 FMD 是颈动脉斑块状态变化的预测因子，但不是 IMT，且与经典心血管危险因素无关。
AIM
It has previously been shown that flow-mediated vasodilation is a predictor of the progression of the intima-media thickness (IMT). In the present study, the degree of endothelium-dependent vasodilation in both resistance and conduit arteries was evaluated as a predictor of the IMT and plaque progression.
METHODS
In the population-based Prospective Study of the Vasculature in Uppsala Seniors(PIVUS) trial(1,016 subjects all 70 years of age), the invasive forearm technique using acetylcholine administered in the brachial artery (resistance artery, EDV) and the brachial artery ultrasound technique with measurement of flow-mediated dilatation (conduit artery, FMD) were evaluated. The IMT and number of carotid arteries with plaques (0, 1 or 2) were recorded using ultrasound at the baseline investigation and the follow-up visit conducted five years later.
RESULTS
A total of 760 subjects had valid measurements of the IMT and carotid artery plaques at both the investigations conducted at 70 and 75 years of age. Neither the FMD nor EDV significantly predicted the change in IMT over five years. However, the FMD, but not EDV, was associated with the change in carotid plaque burden during the follow-up period, independent of classical risk factors, such as gender, waist circumference, fasting blood glucose, systolic and diastolic blood pressure, HDL- and LDL-cholesterol, serum triglycerides, BMI and smoking (OR 0.81 for a 1 SD change in FMD, 95%CI 0.68 to 0.95, p=0.010).
CONCLUSIONS
The FMD was found to be a predictor of changes in the carotid plaque status, but not IMT, during the 5-year follow-up period, independent of classical cardiovascular risk factors.