THE EFFECT OF EPIDERMAL GROWTH-FACTOR MOUTHWASH ON CYTOTOXIC-INDUCED ORAL ULCERATION - A PHASE-I CLINICAL-TRIAL
THE EFFECT OF EPIDERMAL GROWTH-FACTOR MOUTHWASH ON CYTOTOXIC-INDUCED ORAL ULCERATION - A PHASE-I CLINICAL-TRIAL
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DOI：
10.1097/00000421-199510000-00009
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发表时间：
1995-10-01
影响因子：
2.6
通讯作者：
PRINCE, M
中科院分区：
文献类型：
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作者：
GIRDLER, NM;MCGURK, M;PRINCE, M
采用双盲临床试验研究了表皮生长因子(EGF)含漱液对12例癌症化疗患者口腔溃疡愈合和复发的影响。细胞毒性所致溃疡的口腔分布与唾液沟相对应。在试验组和安慰剂组之间，已建立的溃疡的愈合率没有差异。然而，复发性溃疡的开始和严重程度有一个很小的延迟。结论：EGF含漱液不能促进溃疡愈合，但可能具有保护口腔上皮免受细胞毒性损伤的作用。
A double-blind clinical trial was performed to study the effect of epidermal growth factor (EGF) mouthwash on the healing and recurrence of oral ulceration in 12 patients undergoing cancer chemotherapy. The oral distribution of cytotoxic-induced ulcers corresponded to the salivary gutters. There was no difference in the rate of healing of established ulcers between the experimental and placebo groups. However, there was a small delay in the onset and severity of recurrent ulceration. It was concluded that EGF mouthwash does not accelerate ulcer healing, but it may have the potential to protect the oral epithelium from cytotoxic damage.