In situ forming implants for the delivery of metronidazole to periodontal pockets: formulation and drug release studies
In situ forming implants for the delivery of metronidazole to periodontal pockets: formulation and drug release studies
复制标题
DOI：
10.3109/03639045.2013.873449
复制
发表时间：
2014-05-01
影响因子：
3.4
通讯作者：
Bodmeier, Roland
中科院分区：
文献类型：
--
作者：
Kilicarslan, Muge;Koerber, Martin;Bodmeier, Roland
本研究旨在利用生物可降解原位成型种植体将甲硝唑局部释放到牙周袋中，以获得延长的药物释放。研究了聚合物类型（封端和未封端的PLGA）、溶剂类型（水混溶性和水不混溶性）和聚合物/药物比例对体外药物释放研究的影响。具有持续甲硝唑释放和低初始突释的原位植入物由封端的PLGA和作为溶剂的N-甲基-2-吡咯烷酮组成。将粘膜粘附聚合物掺入原位植入物中，以将递送系统的性质改性为在体内停留时间更长。聚合物的加入改变了制剂的粘度并增加了制剂的粘度和药物释放。然而，可实现超过10天的持续药物释放。因此，可生物降解的原位形成植入物是一种有吸引力的递送系统，以实现牙周治疗中甲硝唑的延长释放。
This study was performed to obtain prolonged drug release with biodegradable in situ forming implants for the local delivery of metronidazole to periodontal pockets. The effect of polymer type (capped and uncapped PLGA), solvent type (water-miscible and water-immiscible) and the polymer/drug ratio on in vitro drug release studies were investigated. In situ implants with sustained metronidazole release and low initial burst consisted of capped PLGA and N-methyl-2-pyrolidone as solvent. Mucoadhesive polymers were incorporated into the in situ implants in order to modify the properties of the delivery systems towards longer residence times in vivo. Addition of the polymers changed the adhesiveness and increased the viscosity and drug release of the formulations. However, sustained drug release over 10 days was achievable. Biodegradable in situ forming implants are therefore an attractive delivery system to achieve prolonged release of metronidazole at periodontal therapy.