Adult Right Living‐Donor Liver Transplantation With Special Reference to Reconstruction of the Middle Hepatic Vein

Adult Right Living‐Donor Liver Transplantation With Special Reference to Reconstruction of the Middle Hepatic Vein
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成人右侧活体肝移植,特别是肝中静脉重建

DOI:
10.1111/ajt.12917
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发表时间:
2014
影响因子:
8.8
通讯作者:
N. Kokudo
N. Kokudo
中科院分区:
医学2区
文献类型:
--
作者:
N. Akamatsu;Y. Sugawara;R. Nagata;J. Kaneko;T. Aoki;Y. Sakamoto;K. Hasegawa;N. Kokudo

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将 253 例连续右肝移植(RLG)的活体肝移植受者分为三组:延伸右肝移植(ERLG)组(n = 47),其中肝中静脉(MHV)干被包含在移植物中;改良右肝移植(MRLG)组(n = 114),其中用冷冻保存的同源静脉重建 MHV 支流。和一个简单的RLG组(n = 92),其中MHV支流被牺牲。与其他两组相比,RLG 组的前区体积显着受损,而 RLG 组的后区体积显着改善,表明 MHV 剥夺导致的前区再生受损被后区再生所补偿。 ERLG 组的前房再生率最高(92%),MRLG 组中等(71%),RLG 组最低(52%)。 ERLG组的整个移植物再生率显着高于其他两组。然而,再生不良与功能恢复延迟或长期结果无关。短期内,重建的 MHV 支流的通畅率超过 90%,但长期来看,闭塞频繁发生,尤其是 V5。
Two hundred fifty‐three consecutive living‐donor liver transplant recipients with a right liver graft (RLG) were divided into three groups: an extended right liver graft (ERLG) group (n = 47) in which the middle hepatic vein (MHV) trunk was included in the graft, a modified right liver graft (MRLG) group (n = 114) in which the MHV tributaries were reconstructed with cryopreserved homologous veins and a simple RLG group (n = 92) in which the MHV tributaries were sacrificed. The volume of the anterior sector was significantly impaired in the RLG group compared to the other two groups, whereas the volume of the posterior sector was significantly improved in the RLG group, indicating that the impaired anterior sector regeneration by MHV deprivation was compensated by the posterior sector regeneration. The regeneration rate of the anterior sector was highest in the ERLG group (92%), moderate in the MRLG group (71%) and lowest in the RLG group (52%). The whole graft regeneration rate of the ERLG group was significantly higher than that of the other two groups. Poor regeneration, however, was not correlated with delayed functional recovery or long‐term outcome. Short‐term, the patency of reconstructed MHV tributaries was over 90%, but occlusion occurred frequently over the long‐term, especially in V5.
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