Genetic contribution to biological aging: the Framingham Study.
Genetic contribution to biological aging: the Framingham Study.
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遗传对生物衰老的贡献：弗雷明汉研究。
DOI：
10.1093/gerona/59.3.b218
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发表时间：
2004
期刊：
影响因子：
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通讯作者：
Kiel,DouglasP
中科院分区：
文献类型：
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作者：
Karasik,David;Hannan,MarianT;Cupples,LAdrienne;Felson,DavidT;Kiel,DouglasP
这项研究评估了遗传和非遗传因素对美国白人生物衰老的影响。研究样本包括来自Frachial Heart Study的288个家系的1402名成员。最初的队列参与者在1967-1969年（平均年龄58.7岁）接受了手部X线摄影，他们的后代在1992-1993年（平均年龄51.6岁）接受了手部X线摄影。对手部X线片进行骨显像评分。骨摄影评分系统预测年龄和实际年龄之间的标准化残差被用作生物学年龄（BA）的测量。在方差分量遗传分析中，性别、队列、身高、体重指数，以及女性的绝经状态和雌激素使用，共同解释了BA总方差的约6%。遗传因素解释了另外57%的原因。协变量调整后的BA连锁分析表明，数量性状基因座的存在，染色体3 p，7 q，11 p，16 q和21 q。总之，在美国成年人的样本中，通过X射线摄影测量的BA的变化强烈受遗传因素的影响。
This study assessed the contribution of genetic and nongenetic factors to biological aging in American Caucasians. The studied sample included 1402 members of 288 pedigrees from the Framingham Heart Study. The original cohort participants received hand radiography in 1967–1969 (mean age, 58.7 years) and their offspring in 1992–1993 (mean age, 51.6 years). An osseographic score was applied to hand radiographs. Standardized residuals between Osseographic Scoring System-predicted age and actual age were used as a measure of biological age (BA). In variance component genetic analysis, sex, cohort, height, body mass index, and, in women, menopausal status and estrogen use, jointly explained approximately 6% of the total variance of BA. Genetic factors explained an additional 57%. Linkage analysis of covariate-adjusted BA suggested the presence of quantitative trait loci on chromosomes 3p, 7q, 11p, 16q, and 21q. In conclusion, the variation in BA measured by radiography was strongly governed by genetic factors in a sample of American adults.