Orally delivered alprazolam, diazepam, and triazolam as reinforcers in rhesus monkeys.
Orally delivered alprazolam, diazepam, and triazolam as reinforcers in rhesus monkeys.
复制标题
口服阿普唑仑、地西泮和三唑仑作为恒河猴的强化剂。
DOI：
10.1007/s00213-002-1019-0
复制
发表时间：
2002
影响因子：
3.4
通讯作者：
Meisch,RA
中科院分区：
文献类型：
--
作者：
Gomez,TH;Roache,JD;Meisch,RA
Rationale:Benzodiazepines are among the most frequently prescribed drugs and are usually taken by mouth. However, there have been few studies of oral self-administration of these drugs, and the results of IV self-administration studies indicate that benzodiazepines are modest reinforcers.Objectives:To determine if orally delivered alprazolam, diazepam, and triazolam could serve as reinforcers for rhesus monkeys, and to determine some of the conditions under which benzodiazepine reinforced behavior occurs.Methods:Diazepam or midazolam was initially established as a reinforcer by a fading procedure whereby increasing concentrations were added to a 1 or 2% ethanol solution, and subsequently the ethanol concentration was decreased in steps to zero. Diazepam- and midazolam-reinforced responding persisted in the absence of ethanol. Triazolam and alprazolam served as reinforcers when substituted for diazepam or midazolam.Results:Alprazolam, diazepam, and triazolam served as effective reinforcers across a wide range of concentrations and under fixed-ratio sizes of 16 and 32. Rates of responding were usually far higher than that for the concurrently available vehicle, water. Drug intake (mg drug/kg body weight) generally increased with increases in drug concentration. When large drug amounts were consumed, signs of intoxication were observed.Conclusions:In contrast to reports of low response rates and weakly maintained behavior, the present results show that the three benzodiazepines can serve as effective reinforcers.
