SELECTIVE SUPPRESSION OF RETROVIRAL GP70-ANTI-GP70 IMMUNE-COMPLEX FORMATION BY PROSTAGLANDIN-E1 IN MURINE SYSTEMIC LUPUS-ERYTHEMATOSUS
SELECTIVE SUPPRESSION OF RETROVIRAL GP70-ANTI-GP70 IMMUNE-COMPLEX FORMATION BY PROSTAGLANDIN-E1 IN MURINE SYSTEMIC LUPUS-ERYTHEMATOSUS
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DOI：
10.1084/jem.152.6.1645
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发表时间：
1980-01-01
影响因子：
15.3
通讯作者：
DIXON, FJ
中科院分区：
文献类型：
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作者：
IZUI, S;KELLEY, VE;DIXON, FJ
在3个品系的小鼠（NZB × PGE）中研究了前列腺素E1（PGE）的药理学量的作用。NZW、MRL/1和BXSB），自发发生狼疮样肾小球肾炎。PGE治疗延长了NZB的存活期，并延缓了肾小球免疫复合物（IC）沉积和肾小球肾炎的发展。NZW和MRL/1小鼠，但没有类似的保护BXSB小鼠。与未处理的对照组相比，响应菌株的变化与循环gp 70与抗gp 70抗体复合的量减少密切相关，尽管血清中可检测到的gp 70（游离和复合）的总浓度在两组中相似。PGE可选择性地抑制对逆转录病毒gp 70的免疫应答; PGE对抗DNA抗体的数量和质量影响不大，但能减少含抗DNA IC的抗体在肾脏的沉积; gp 70 IC在小鼠系统性红斑狼疮肾炎的发病机制中起重要作用。
The effect of pharmacologic quantities of prostaglandin E1 (PGE) was investigated in 3 strains of mice (NZB .times. NZW, MRL/1 and BXSB) that spontaneously develop lupus-like glomerulonephritis. PGE-treatment prolonged survival and retarded the glomerular immune complex (IC) deposition and the development of glomerulonephritis in NZB .times. NZW and MRL/1 mice, but did not similarly protect BXSB mice. Changes in the responsive strains correlated well with reduced amounts of circulating gp70 complexed with anti-gp70 antibodies compared with untreated controls, although total concentrations of gp70 (free and complexed) detectable in sera were similar in both groups. Apparently, PGE selectively suppressed the immune response to retroviral gp70; PGE had little effect on the quantity or quality of anti-DNA antibodies but did reduce the deposition of anti-DNA containing IC in the kidney; and gp70 IC appear to play an important role in the glomerulonephritis pathogenesis in murine systemic lupus erythematosus.