Effects of a psychosocial family-based preventive intervention on cortisol response to a social challenge in preschoolers at high risk for antisocial behavior
Effects of a psychosocial family-based preventive intervention on cortisol response to a social challenge in preschoolers at high risk for antisocial behavior
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DOI：
10.1001/archpsyc.64.10.1172
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发表时间：
2007-10-01
影响因子：
--
通讯作者：
Pine, Daniel S.
中科院分区：
文献类型：
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作者：
Brotman, Laurie Miller;Gouley, Kathleen Kiely;Pine, Daniel S.
背景：社会挑战期间的唾液皮质醇水平与儿童和成人的适应功能有关。低皮质醇水平与行为问题和反社会行为有关。虽然啮齿动物的研究暗示早期生活的社会经验在皮质醇regulation.Objective的社会经验的实验操纵的影响，没有研究与人类已经检查了早期生活的社会经验对皮质醇regulation.Objective的影响：检查实验操纵的社会经验对皮质醇反应的社会挑战学龄前儿童在危险的反社会行为。设计：随机对照试验。纽约大学医学院儿童和青少年精神病学系。参与者：92名因犯罪行为而被判定的学龄前青年兄弟姐妹。干预：以家庭为基础的干预包括在6至8个月期间为父母和学龄前儿童进行22次每周小组会议和10次双周家访。主要结果测量：唾液皮质醇水平之前和之后的社会挑战（进入一个不熟悉的同龄人组）。结果：相对于对照组，儿童在干预条件下增加皮质醇水平的预期同行的社会挑战。增加是相对于两个干预前的皮质醇水平在挑战和皮质醇水平在家里，这并没有改变的intervention.Conclusions：一个以家庭为基础的预防性干预，在高风险的儿童反社会行为改变压力反应的预期，一个同龄人的社会挑战。实验引起的皮质醇水平的变化与正常发育的低风险儿童的模式相似。
Context: Salivary cortisol levels during social challenge relate to adaptive functioning in children and adults. Low cortisol levels have been related to conduct problems and antisocial behavior. Although studies in rodents implicate early- life social experience in cortisol regulation, no studies with humans have examined the effects of an experimentally manipulated early- life social experience on cortisol regulation.Objective: To examine the effects of experimental manipulations of social experience on cortisol response to a social challenge in preschoolers at risk for antisocial behavior.Design: Randomized controlled trial.Setting: Department of Child and Adolescent Psychiatry, New York University School of Medicine.Participants: Ninety- two preschool- age siblings of youths adjudicated for delinquent acts.Intervention: Family- based intervention included 22 weekly group sessions for parents and preschoolers and 10 biweekly home visits conducted during a 6- to 8- month period.Main Outcome Measures: Salivary cortisol levels before and after a social challenge ( entry into an unfamiliar peer group).Results: Relative to controls, children in the intervention condition had increased cortisol levels in anticipation of the peer social challenge. Increases were relative to both preintervention cortisol levels during the challenge and cortisol levels in the home, which were not altered by the intervention.Conclusions: A family- based preventive intervention for children at high risk for antisocial behavior alters stress response in anticipation of a peer social challenge. The experimentally induced change in cortisol levels parallels patterns found in normally developing, low- risk children.