Species-specific homogeneity of the primate Alu family of repeated DNA sequences.
Species-specific homogeneity of the primate Alu family of repeated DNA sequences.
复制标题
灵长类 Alu 家族重复 DNA 序列的物种特异性同质性。
DOI：
10.1093/nar/11.21.7579
复制
发表时间：
1983
影响因子：
14.9
通讯作者：
Deininger,PL
中科院分区：
文献类型：
--
作者：
Daniels,GR;Fox,GM;Loewensteiner,D;Schmid,CW;Deininger,PL
我们已经确定了几个克隆的Alu家族成员的碱基序列从一个新的世界猴（猫头鹰猴）和原猴（galago）的DNAs。本文报道的三个猫头鹰猴Alu家族成员属于一个单一的300个碱基对的共有序列，该序列与人类Alu家族的共有序列非常相似。galago Alu家族成员可以最好地表示为属于两个相关但不同的共有序列中的任一个。两个galago Alu家族亚群（I型）的Che比另一个亚群（II型）更准确地类似于人类共有序列。在这项工作中，我们比较了人类和galago I型Alu家族成员的碱基序列。人类和I型galago序列之间存在物种特异性差异的几个例子表明Alu家族成员在一个物种内是有效同质化的。
We have determined the base sequence of several cloned Alu family members from the DNAs of a new world monkey (owl monkey) and a prosimian (galago). The three owl monkey Alu family members reported here belong to a single 300 base pair consensus sequence tfiich closely resembles the human Alu family consensus. The galago Alu family members can best be represented as belonging to either of two related but distinct consensus sequences. Che of the two galago Alu family subgroups (Type I) more accurately resembles the human consensus sequence than does the other subgroup (Type II). In this work we compare base sequences of human and galago Type I Alu family members. There are several examples of species-specific differences between the human and Type I galago sequences indicating that the Alu family members are effectively homogenized within a species.