Catheter-based endomyocardial injection with real-time magnetic resonance imaging.
Catheter-based endomyocardial injection with real-time magnetic resonance imaging.
复制标题
基于导管的心内膜心肌注射与实时磁共振成像。
DOI：
10.1161/01.cir.0000012425.71261.fc
复制
发表时间：
2002
期刊：
影响因子：
37.8
通讯作者：
McVeigh,ElliotR
中科院分区：
文献类型：
--
作者：
Lederman,RobertJ;Guttman,MichaelA;Peters,DanaC;Thompson,RichardB;Sorger,JonathanM;Dick,AlexanderJ;Raman,VenkateshK;McVeigh,ElliotR
Background—We tested the feasibility of targeted left ventricular (LV) mural injection using real-time MRI (rtMRI).Methods and Results—A 1.5T MRI scanner was customized with a fast reconstruction engine, transfemoral guiding catheter–receiver coil (GCC), MRI-compatible needle, and tableside consoles. Commercial real-time imaging software was customized to facilitate catheter navigation and visualization of injections at 4 completely refreshed frames per second. The aorta was traversed and the left ventricular cavity was entered under direct rtMRI guidance. Pigs underwent multiple injections with dilute gadolinium-DTPA. All myocardial segments were readily accessed. The active GCC and the passive Stiletto needle injector were readily visualized. More than 50 endomyocardial injections were performed with the aid of rtMRI; 81% were successful with this first-generation prototype.Conclusion—Percutaneous endomyocardial drug delivery is feasible with the aid of rtMRI, which permits precise 3-dimensional localization of injection within the LV wall.
