Apolipoprotein E epsilon4 positive individuals demonstrate delayed olfactory event-related potentials.
Apolipoprotein E epsilon4 positive individuals demonstrate delayed olfactory event-related potentials.
复制标题
载脂蛋白 E epsilon4 阳性个体表现出延迟的嗅觉事件相关电位。
DOI：
10.1016/s0197-4580(01)00215-9
复制
发表时间：
2001
影响因子：
4.2
通讯作者：
Murphy,C
中科院分区：
文献类型：
--
作者：
Wetter,S;Murphy,C
载脂蛋白 E ε4 阳性个体在识别和记忆气味的能力上存在缺陷，嗅觉功能的心理物理测量表明。本研究的目的是使用客观的电生理测量：嗅觉事件相关电位（OERP）来识别该人群的嗅觉缺陷。在单刺激范例中，从 10 名 ε4 阳性个体和 10 名年龄和性别匹配的 ε4 阴性个体的 Fz、Cz 和 Pz 电极位点记录嗅觉和听觉 ERP。结果表明：（1）载脂蛋白 E ε4 等位基因呈阳性的个体与 ε4 阴性的个体相比，在嗅觉信息处理方面表现出延迟（约 100 毫秒）； (2) OERP潜伏期比嗅觉功能的心理物理测量更敏感； (3) OERP 认知 P3 部分的延迟与识别气味的能力缺陷有关； (4) 与听觉 ERP 中发现的中等范围不同，OERP 潜伏期在分类 ε4 阳性和阴性个体时表现出高敏感性和特异性。
Apolipoprotein E ε4 positive individuals have deficits in the ability to identify and remember odors, as demonstrated by psychophysical measures of olfactory function. The purpose of the present study was to identify olfactory deficits in this population using an objective electrophysiological measure: the olfactory event-related potential (OERP). Olfactory and auditory ERPs were recorded from the Fz, Cz, and Pz electrode sites in 10 ε4 positive individuals and 10 age and gender-matched ε4 negative individuals in a single-stimulus paradigm. The results indicate: (1) individuals who are positive for the apolipoprotein E ε4 allele demonstrated delays (of approximately 100 ms) in the processing of olfactory information compared to those who are ε4 negative; (2) OERP latency is more sensitive than psychophysical measures of olfactory function; (3) delays in the cognitive P3 component of the OERP are associated with deficits in the ability to identify an odor; and (4) unlike the moderate ranges found in auditory ERP, OERP latency showed high sensitivity and specificity in classifying ε4 positive and negative individuals.