Association between prefrontal hemodynamic responses during cognitive task and subjective quality of life in schizophrenia
Association between prefrontal hemodynamic responses during cognitive task and subjective quality of life in schizophrenia
复制标题
精神分裂症认知任务期间前额叶血流动力学反应与主观生活质量之间的关联
DOI：
10.1016/j.schres.2013.11.008
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发表时间：
2014
影响因子：
4.5
通讯作者：
Koichi Kaneko
中科院分区：
文献类型：
--
作者：
Shenghong Pu;Kazuyuki Nakagome;Takeshi Yamada;Megumi Itakura;Takahiro Satake;Hisahito Ishida;Izumi Nagata;Koichi Kaneko
本研究的主要目的是利用 52 通道近红外光谱 (NIRS) 调查精神分裂症患者前额皮质 (PFC) 活动与主观生活质量 (QOL) 之间的确切关系。 38 名（22 名女性，16 名男性）临床稳定、能够接受评估且满足年龄标准、年龄在 18-60 岁之间（平均年龄为 32.8±10.95）的精神分裂症患者参与了该研究。在解释本研究结果时，还需要考虑其他一些方法学局限性。首先，与 fMRI 和 PET 相比，多通道 NIRS 的空间分辨率有限。总之，这是第一项专门研究精神分裂症患者主观生活质量背后的皮质神经机制的 NIRS 研究。前额叶和左颞上皮质的氧合血红蛋白变化与主观生活质量显着相关。这表明这些区域的神经活动与主观生活质量相关，并且通过无创 NIRS 技术评估的血流动力学反应可能是有用的生物标记。（PsycINFO 数据库记录 (c) 2017 APA，保留所有权利）
The primary objective of the present study was to investigate the exact relationship between activity in the prefrontal cortex (PFC) and subjective quality of life (QOL) in patients with schizophrenia, using 52-channel near-infrared spectroscopy (NIRS). Thirty-eight (22 female, 16 male) patients with schizophrenia who were clinically stable enough to undergo the assessment and satisfied the age criteria, and were within 18–60 years (mean age, 32.8±10.95), participated in the study. There are some other methodological limitations to consider when interpreting the results of this study. Firstly, multi-channel NIRS has limited spatial resolution in comparison with fMRI and PET. In summary, this is the first NIRS study to specifically investigate the cortical neural mechanisms underlying subjective QOL in schizophrenia patients. Oxy-Hb changes in the prefrontal and left superior temporal cortices were significantly associated with subjective QOL. This suggests that neural activity in these areas is associated with subjective QOL, and that hemodynamic responses assessed by noninvasive NIRS techniques might be a useful biological marker.(PsycINFO Database Record (c) 2017 APA, all rights reserved)