Adaptive gain and the role of the locus coeruleus-norepinephrine system in optimal performance
Adaptive gain and the role of the locus coeruleus-norepinephrine system in optimal performance
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DOI：
10.1002/cne.20723
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发表时间：
2005-12-05
影响因子：
2.5
通讯作者：
Cohen, JD
中科院分区：
文献类型：
--
作者：
Aston-Jones, G;Cohen, JD
从历史上看，蓝斑-去甲肾上腺素（LC-NE）系统与觉醒有关，但最近的研究结果表明，该系统在行为控制中发挥的作用比研究人员之前认为的更为复杂和具体。我们回顾了猴子的神经生理学、解剖学和建模研究，这些研究支持了 LC-NE 功能的新理论。 LC 神经元表现出两种活动模式：阶段性和强直性。阶段性 LC 激活由任务相关决策过程的结果驱动，旨在促进后续行为并帮助优化任务绩效。当任务效用减弱时，LC 神经元会表现出一种紧张性活动模式，与脱离当前任务和寻找替代行为相关。猴子 LC 接收来自前扣带皮层 (ACC) 和眶额皮质 (OFC) 的显着的直接输入，这两个区域都被认为可以监控任务相关的效用。我们建议这些前额叶区域产生上述 LC 活动模式，以优化短期和长期表现的效用。
Historically, the locus coeruleus-norepinephrine (LC-NE) system has been implicated in arousal, but recent findings suggest that this system plays a more complex and specific role in the control of behavior than investigators previously thought. We review neurophysiological, anatomical, and modeling studies in monkey that support a new theory of LC-NE function. LC neurons exhibit two modes of activity, phasic and tonic. Phasic LC activation is driven by the outcome of task-related decision processes and is proposed to facilitate ensuing behaviors and to help optimize task performance. When utility in the task wanes, LC neurons exhibit a tonic activity mode, associated with disengagement from the current task and a search for alternative behaviors. Monkey LC receives prominent, direct inputs from the anterior cingulate (ACC) and orbitofrontal cortices (OFC), both of which are thought to monitor task-related utility. We propose that these prefrontal areas produce the above patterns of LC activity to optimize the utility of performance on both short and long time scales.