Ion channels in the central regulation of energy and glucose homeostasis.

Ion channels in the central regulation of energy and glucose homeostasis.
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DOI:
10.3389/fnins.2013.00085
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发表时间:
2013
影响因子:
4.3
通讯作者:
Sohn JW
Sohn JW
中科院分区:
医学2区
文献类型:
--
作者:
Sohn JW

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离子通道是大脑神经元兴奋性和突触功能的关键调节器。最近的证据表明,大脑内神经元表达的离子通道负责调节能量和葡萄糖稳态。此外,神经递质和激素的中枢作用至少部分是通过改变离子通道活性来实现的。本综述重点关注离子通道及其神经元功能,随后讨论了特定离子通道在调节食物摄入、能量消耗和葡萄糖平衡的中央途径中的已确定作用。
Ion channels are critical regulators of neuronal excitability and synaptic function in the brain. Recent evidence suggests that ion channels expressed by neurons within the brain are responsible for regulating energy and glucose homeostasis. In addition, the central effects of neurotransmitters and hormones are at least in part achieved by modifications of ion channel activity. This review focuses on ion channels and their neuronal functions followed by a discussion of the identified roles for specific ion channels in the central pathways regulating food intake, energy expenditure, and glucose balance.
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