Human immunodeficiency virus-related microbial translocation and progression of hepatitis C
Human immunodeficiency virus-related microbial translocation and progression of hepatitis C
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DOI：
10.1053/j.gastro.2008.03.022
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发表时间：
2008-07-01
期刊：
影响因子：
29.4
通讯作者：
Ray, Stuart C.
中科院分区：
文献类型：
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作者：
Balagopal, Ashwin;Philp, Frances H.;Ray, Stuart C.
背景和目标：人类免疫缺陷病毒（HIV）-I感染与增强的微生物易位有关，并且微生物易位是酒精和一些肠道疾病引起肝脏疾病的机制。我们假设HIV通过促进微生物易位而促进肝脏疾病。方法：我们研究了丙型肝炎病毒（HCV）和艾滋病毒结局被仔细描述的人类队列。结果如下：HIV相关的CD 4（+）淋巴细胞耗竭与微生物易位密切相关，如循环脂多糖（LPS）、LPS结合蛋白、可溶性CD 14、和岩藻糖结合凝集素（AAL），与α-半乳糖表位特异性免疫球蛋白G反应，并抑制内毒素核心抗体水平（EndoCAb IgM）在HIV感染受试者中与HIV感染前相同的人相比，并与HIV未感染受试者相比。同样的微生物易位指标与HCV相关肝病进展（肝硬化）密切相关，例如，LPS，比值比为19.0（P =.002）; AAL，比值比为27.8（P
Background&Aims: Human immunodeficiency virus (HIV)-l infection has been associated with enhanced microbial translocation, and microbial translocation is a mechanism through which alcohol and some enteric conditions cause liver disease. We hypothesized that HIV promotes liver disease by enhancing microbial translocation. Methods: We studied human cohorts in which hepatitis C virus (HCV) and HIV outcomes were carefully characterized. Results: HIV-related CD4(+) lymphocyte depletion was strongly associated with microbial translocation as indicated by elevated levels of circulating hpopolysaccharide (LPS), LPS-binding protein, soluble CD14, and fucose-binding lectin (AAL) reactive to immunoglobulin G specific for the a-galactose epitope and suppressed levels of endotoxin core antibodies (EndoCAb IgM) in HIV-infected subjects compared with the same persons before they had HIV infection and compared with HIV-uninfected subjects. The same measures of microbial translocation were strongly associated with HCV-related liver disease progression (cirrhosis), eg, LPS, odds ratio, 19.0 (P =.002); AAL, odds ratio, 27.8 (P