Effect of weight loss with reduction of intra-abdominal fat on lipid metabolism in older men.
Effect of weight loss with reduction of intra-abdominal fat on lipid metabolism in older men.
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DOI：
10.1210/jcem.85.3.6402
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发表时间：
2000-03
期刊：
影响因子：
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通讯作者：
J. Purnell;S. Kahn;J. Albers;D. Nevin;J. Brunzell;Robert S. Schwartz
中科院分区：
文献类型：
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作者：
J. Purnell;S. Kahn;J. Albers;D. Nevin;J. Brunzell;Robert S. Schwartz
人们对减肥如何改善血脂水平知之甚少。横断面研究表明，脂肪在腹腔内储存（IAF）中的积聚可能导致脂质水平异常、肝脂酶（HL）活性增加和低密度脂蛋白（LDL）颗粒尺寸变小。为了确定IAF的损失对脂质参数的影响，21名健康的老年男性进行了饮食诱导的体重减轻。在体重减轻前后的体重稳定期内，受试者接受了身体成分、脂质、肝素后脂蛋白和HL脂肪酶活性测量、胆固醇酯转移蛋白活性和胰岛素敏感性（Si）研究。在平均体重减轻10%后，脂肪量、IAF和腹部s.c.观察到脂肪，伴随甘油三酯、极低密度脂蛋白胆固醇、载脂蛋白B和HL活性水平降低。高密度脂蛋白-2胆固醇和硅增加。在基线时具有模式B LDL的受试者中，LDL颗粒大小增加。胆固醇酯转运蛋白活性没有变化。IAF和Si的变化与HL活性降低相关（尽管并非相互独立）。总之，在接受饮食诱导的体重减轻的男性中，仅发现IAF的减少与HL减少相关，HL减少与对脂质水平的有益作用相关。
How weight loss improves lipid levels is poorly understood. Cross-sectional studies have suggested that accumulation of fat in intra-abdominal stores (IAF) may lead to abnormal lipid levels, increased hepatic lipase (HL) activity, and smaller low density lipoprotein (LDL) particle size. To determine what effect loss of IAF would have on lipid parameters, 21 healthy older men underwent diet-induced weight loss. During a period of weight stability before and after weight loss, subjects underwent studies of body composition, lipids, measurement of postheparin lipoprotein and HL lipase activities, cholesteryl ester transfer protein activity, and insulin sensitivity (Si). After an average weight loss of 10%, reductions in fat mass, IAF, and abdominal s.c. fat were seen, accompanied by reductions in levels of triglyceride, very low density lipoprotein cholesterol, apolipoprotein B, and HL activity. High density lipoprotein-2 cholesterol and Si increased. In those subjects with pattern B LDL at baseline, LDL particle size increased. Cholesteryl ester transfer protein activity did not change. Changes in IAF and Si correlated with a decrease in HL activity (although not independently of each other). In summary, in men undergoing diet-induced weight loss, only loss of IAF was found to be associated with a reduction in HL, which is associated with beneficial effects on lipid levels.