A non‐canonical photopigment, melanopsin, is expressed in the differentiating ganglion, horizontal, and bipolar cells of the chicken retina
A non‐canonical photopigment, melanopsin, is expressed in the differentiating ganglion, horizontal, and bipolar cells of the chicken retina
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DOI：
10.1002/dvdy.20600
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发表时间：
2005-11
影响因子：
2.5
通讯作者：
S. Tomonari;Akira Takagi;Shin-ichi Akamatsu;S. Noji;H. Ohuchi
中科院分区：
文献类型：
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作者：
S. Tomonari;Akira Takagi;Shin-ichi Akamatsu;S. Noji;H. Ohuchi
脊椎动物黑素是眼睛中的一种光色素，需要光包裹。黑色素与无脊椎动物中发现的视蛋白的关系比与其他光色素的关系更密切。虽然无脊椎动物的黑素样蛋白定位于无脊椎动物的横纹体光感受器中，但在小鼠的视网膜神经节细胞和青蛙的水平细胞中都有表达，这表明它在脊椎动物中的表达模式是多样化的。在这里，我们展示了两种类型的黑素转录本在发育中的鸡视网膜中表达。在发育中的鸡视网膜中，黑素首先由一小部分神经节细胞表达，然后由水平细胞显著表达，最后由双极细胞表达。这表明鸡视网膜中的神经节细胞、水平细胞和双极细胞的子集可能在其起源时具有横纹体特性。《发展动力学》234：783-790,2005。©2005 Wiley-Liss Inc.
Vertebrate melanopsin is a photopigment in the eye, required for photoentrainment. Melanopsin is more closely related to opsin proteins found in invertebrates, than to the other photo‐pigments. Although the invertebrate melanopsin‐like protein is localized in rhabdomeric photoreceptors in the invertebrate eye, it has been shown to be expressed in a subset of retinal ganglion cells in the mouse and in horizontal cells in the frog, indicating its diversified expression pattern in vertebrates. Here we show that two types of melanopsin transcripts are expressed in the developing chicken retina. Melanopsin is firstly expressed by a small subset of ganglion cells, and then prominently expressed by horizontal cells and later by bipolar cells in the developing chicken retina. This suggests that a subset of ganglion, horizontal, and bipolar cells in the chicken retina may have rhabdomeric properties in their origins. Developmental Dynamics 234:783–790, 2005. © 2005 Wiley‐Liss, Inc.