LEWY BODIES OF PARKINSONS-DISEASE CONTAIN NEUROFILAMENT ANTIGENS
LEWY BODIES OF PARKINSONS-DISEASE CONTAIN NEUROFILAMENT ANTIGENS
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DOI：
10.1126/science.6308771
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发表时间：
1983-01-01
期刊：
影响因子：
56.9
通讯作者：
PERESS, NS
中科院分区：
文献类型：
--
作者：
GOLDMAN, JE;YEN, SH;PERESS, NS
路易体是帕金森病的组织学标志，是一种丝状包涵体，主要存在于脑干的色素神经元中。用神经系统的几种丝状蛋白的抗血清检测路易体的免疫细胞化学反应，发现与神经丝的抗血清呈阳性反应。神经元细胞骨架的异常组织可能是帕金森病的病理特征。
The Lewy body, a histological hallmark of Parkinson''s disease, is a filamentous inclusion residing most prominently in pigmented neurons of the brainstem. Immunocytochemical reactions of Lewy bodies were examined with antisera to several filamentous proteins of the nervous system and positive reactions were found with those against neurofilaments. An abnormal organization of the neuronal cytoskeleton may be a pathological feature of Parkinson''s disease.