Pathological synchronisation in the subthalamic nucleus of patients with Parkinson's disease relates to both bradykinesia and rigidity
Pathological synchronisation in the subthalamic nucleus of patients with Parkinson's disease relates to both bradykinesia and rigidity
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DOI：
10.1016/j.expneurol.2008.11.008
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发表时间：
2009-02-01
影响因子：
5.3
通讯作者：
Brown, Peter
中科院分区：
文献类型：
--
作者：
Kuehn, Andrea A.;Tsui, Alexander;Brown, Peter
帕金森病 (PD) 与基底神经节频率超过 8-35 Hz 的过度振荡同步有关。研究表明，用多巴胺前药左旋多巴治疗后，丘脑底核 (STN) 的局部场电位 (LFP) 活动受到抑制，8-35 Hz 频段功率的抑制程度与运动迟缓和强直综合测量的改善相关。然而，这些研究并没有明确解决以下问题：在预测临床变化时更重要的是后者发生的 8-35 Hz 频带内特定频率的神经元活动的同步。此外，他们还没有证明治疗引起的同步变化与运动迟缓或强直本身的变化之间的关系。为此，我们收集并分析了30例PD患者的LFP和临床数据。当单独考虑这些临床特征时，但仅当功率抑制曲线与峰值同步频率重新对齐时，我们发现左旋多巴引起的功率抑制与僵硬和运动迟缓之间存在显着相关性。在这种情况下，尽管部分消除了运动迟缓的影响，但与僵硬的相关性仍然存在，反之亦然。这些数据表明，左旋多巴引起的僵硬和运动迟缓的改善与 STN LFP 中振荡功率的抑制程度成正比，并且无论在 8-35 Hz 的宽带上发生同步的频率如何，这一点都是正确的。 (c) 2008 Elsevier Inc. 保留所有权利。
Parkinson's disease (PD) is associated with exaggerated oscillatory synchrony in the basal ganglia at frequencies over 8-35 Hz. Studies have demonstrated a suppression of local field potential (LFP) activity in the subthalamic nucleus (STN) upon treatment with the dopamine prodrug, levodopa, with the degree of suppression of power in the 8-35 Hz band correlating with the improvement in combined measures of bradykinesia and rigidity. However, these studies do not explicitly address the question of what is more important in predicting clinical change - synchronisation of neuronal activity OF the specific frequency within the 8-35 Hz band over which the latter occurs. In addition, they have not demonstrated a relationship between treatment-induced changes in synchronisation and changes in bradykinesia or rigidity on their own. To this end, we collected and analysed LFP and clinical data in 30 patients with PD. We found significant correlations between levodopa-induced power suppression and rigidity and bradykinesia, when these clinical features were considered separately, but only when power suppression profiles were re-aligned to the frequency of peak synchronisation. Under these circumstances Correlations with rigidity persisted despite partialising out the effect of bradykinesia and vice versa. These data suggest that levodopa-induced improvements in both rigidity and bradykinesia scale with the degree of suppression of oscillatory power in the STN LFP, and that this is true irrespective of the frequency at which synchronisation occurs across a broad band from 8-35 Hz. (c) 2008 Elsevier Inc. All rights reserved.