Principles of protein-protein interactions
Principles of protein-protein interactions
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DOI：
10.1093/bioinformatics/18.suppl_2.s249
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发表时间：
2002-10
期刊：
影响因子：
5.8
通讯作者：
S. Teichmann
中科院分区：
文献类型：
--
作者：
S. Teichmann
在后基因组时代，最有趣和最重要的挑战之一是大规模地了解蛋白质相互作用。蛋白质结构域之间的物理相互作用是细胞工作的基础：在多结构域多肽链中，在多亚基蛋白质中，以及在独立存在的蛋白质之间的瞬时复合物中。因此，蛋白质-蛋白质相互作用的实验研究已经广泛，包括最近使用质谱的大规模筛选。蛋白质-蛋白质相互作用的计算研究的作用不仅包括预测，还包括理解相互作用的性质及其三维结构。我将讨论的性质，如序列保守性和共同调控的基因和蛋白质参与不同类型的物理相互作用。鉴于所有蛋白质都由它们的进化单位--结构域组成，所有的相互作用都发生在这些结构域之间。属于不同蛋白质家族的结构域之间的相互作用将是我演讲的第二个主题。
In the postgenomic era, one of the most interesting and important challenges is to understand protein interactions on a large scale. The physical interactions between protein domains are fundamental to the workings of a cell: in multi-domain polypeptide chains, in multi-subunit proteins and in transient complexes between proteins that also exist independently. Thus experimental investigation of protein-protein interactions has been extensive, including recent large-scale screens using mass spectrometry. The role of computational research on protein-protein interactions encompasses not only prediction, but also understanding the nature of the interactions and their three-dimensional structures. I will discuss properties such as sequence conservation and co-regulation of genes and proteins involved in different types of physical interactions. Given that all proteins consist of their evolutionary units, the domains, all interactions occur between these domains. The interactions between domains belonging to different protein families will be the second topic of my talk.