Neuroblastoma
Neuroblastoma
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DOI：
10.1615/critrevoncog.2015014033
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发表时间：
2015-01-01
影响因子：
--
通讯作者：
Eggert, Angelika
中科院分区：
文献类型：
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作者：
Schulte, Johannes H.;Eggert, Angelika
神经母细胞瘤是儿童最常见的颅外实体瘤。自150年前首次描述以来，其神秘的临床表现一直在挑战临床医生和吸引基础研究人员。本文概述了神经母细胞瘤的主要临床特征和目前的治疗方法。它还强调了我们对交感肾上腺发育生物学的理解，再加上转录组分析，下一代测序，全基因组关联和表观遗传学研究，阐明了神经母细胞瘤肿瘤发生中涉及的关键信号转导途径，并确定了临床开发的治疗上易于处理的靶点。
Neuroblastoma is the most common extracranial solid tumor in children. Since its first description some 150 years ago, its enigmatic clinical presentation has challenged clinicians and fascinated basic researchers. This article presents an overview of the key clinical features of neuroblastoma and current therapeutic approaches. It also highlights how our understanding of sympathoadrenal developmental biology, coupled with transcriptome analyses, next-generation sequencing, and genome-wide association and epigenetic studies, has illuminated critical signal transduction pathways involved in neuroblastoma tumorigenesis and identified therapeutically tractable targets for clinical development.