A natural heme deficiency exists in biology that allows nitric oxide to control heme protein functions by regulating cellular heme distribution.
A natural heme deficiency exists in biology that allows nitric oxide to control heme protein functions by regulating cellular heme distribution.
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生物学中存在天然血红素缺乏，使得一氧化氮能够通过调节细胞血红素分布来控制血红素蛋白功能。
DOI：
10.1002/bies.202300055
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Jayaram,DhanyaThamaraparambil
中科院分区：
文献类型：
--
作者：
Stuehr,DennisJ;Biswas,Pranjal;Dai,Yue;Ghosh,Arnab;Islam,Sidra;Jayaram,DhanyaThamaraparambil
存在于循环外的细胞中的天然血红素缺乏广泛地损害细胞和组织中的血红素含量和血红素蛋白的功能。最近，我们发现信号分子一氧化氮（NO）可以以浓度依赖性的兴奋方式触发或抑制细胞内血红素的部署。这揭示了NO的新作用，并为它通过控制血红素部署和随后的血红素蛋白在生物学中的功能来塑造许多生物过程奠定了基础。
A natural heme deficiency that exists in cells outside of the circulation broadly compromises the heme contents and functions of heme proteins in cells and tissues. Recently, we found that the signaling molecule, nitric oxide (NO), can trigger or repress the deployment of intracellular heme in a concentration‐dependent hormetic manner. This uncovers a new role for NO and sets the stage for it to shape numerous biological processes by controlling heme deployment and consequent heme protein functions in biology.