Natural compound-derived epigenetic regulators targeting epigenetic readers, writers and erasers.
Natural compound-derived epigenetic regulators targeting epigenetic readers, writers and erasers.
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DOI：
10.2174/1568026615666150826114359
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发表时间：
2016
影响因子：
3.4
通讯作者：
Kong AN
中科院分区：
文献类型：
--
作者：
Yang AY;Kim H;Li W;Kong AN
翻译后修饰可以以一种长期的方式影响基因表达，而不会改变DNA的初级核苷酸序列。这些表观遗传改变涉及发生在组蛋白、染色质相关蛋白和DNA中的动态过程。作为对环境刺激的反应，异常的表观遗传改变会导致细胞周期、细胞凋亡和其他细胞过程的紊乱，从而导致包括癌症在内的各种疾病的发生。在这篇综述中，我们将总结最近的研究，重点是与癌症发展相关的某些表观遗传学读者、作家和擦除器，以及新发现的天然化合物及其衍生物如何与这些靶点相互作用。这些进展提供了对癌症表观遗传改变的洞察，以及这些改变作为未来化学预防和化疗药物开发的治疗靶点的潜在用途。
Post-translational modifications can affect gene expression in a long-term manner without changes in the primary nucleotide sequence of the DNA. These epigenetic alterations involve dynamic processes that occur in histones, chromatin-associated proteins and DNA. In response to environmental stimuli, abnormal epigenetic alterations cause disorders in the cell cycle, apoptosis and other cellular processes and thus contribute to the incidence of diverse diseases, including cancers. In this review, we will summarize recent studies focusing on certain epigenetic readers, writers, and erasers associated with cancer development and how newly discovered natural compounds and their derivatives could interact with these targets. These advances provide insights into epigenetic alterations in cancers and the potential utility of these alterations as therapeutic targets for the future development of chemopreventive and chemotherapeutic drugs.