Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior
Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior
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DOI：
10.1016/s0092-8674(00)80949-6
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发表时间：
1998-02-20
期刊：
影响因子：
64.5
通讯作者：
Yanagisawa, M
中科院分区：
文献类型：
--
作者：
Sakurai, T;Amemiya, A;Yanagisawa, M
下丘脑在摄食和能量平衡的综合控制中起着核心作用。我们已经确定了两种新的神经肽，它们都是通过蛋白水解加工从相同的前体中衍生出来的，它们结合并激活了两个密切相关的孤儿G蛋白偶联受体。这些肽，被称为食欲素- a和-B，与已知的调节肽家族没有明显的结构相似性。成年大鼠大脑中，食欲素前原mRNA和免疫反应性食欲素a定位于外侧和后下丘脑内和周围的神经元。当给老鼠集中注射时，这些肽刺激食物消耗。pre - pro-orexin mRNA水平在禁食时上调，提示多肽在调节摄食行为的中枢反馈机制中作为介质的生理作用。
The hypothalamus plays a central role in the integrated control of feeding and energy homeostasis. We have identified two novel neuropeptides, both derived from the same precursor by proteolytic processing, that bind and activate two closely related (previously) orphan G protein-coupled receptors. These peptides, termed orexin-A and -B, have no significant structural similarities to known families of regulatory peptides. prepro-orexin mRNA and immunoreactive orexin-A are localized in neurons within and around the lateral and posterior hypothalamus in the adult rat brain. When administered centrally to rats, these peptides stimulate food consumption. prepro-orexin mRNA level is up-regulated upon fasting, suggesting a physiological role for the peptides as mediators in the central feedback mechanism that regulates feeding behavior.