Cross-regulation among the Polycomb group genes in Drosophila melanogaster
Cross-regulation among the Polycomb group genes in Drosophila melanogaster
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DOI：
10.1128/mcb.24.17.7737-7747.2004
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发表时间：
2004-09-01
影响因子：
5.3
通讯作者：
Bender, W
中科院分区：
文献类型：
--
作者：
Ali, JY;Bender, W
黑腹果蝇中的Polycomb组基因作为长期转录抑制因子发挥作用。该组的一些成员编码在两种进化上保守的染色质复合物中发现的蛋白质，多梳抑制复合物1（PRC 1）和ESC-E（Z）复合物。大多数的组，缺乏明确的生化功能，可能是间接调节。在该家族中的各种其他基因的胚胎突变体中检测了7个Polycomb组基因的转录水平。三个Polycomb基因被鉴定为PRC 1核心组分的上游正调控基因，其他PRC 1基因也对PRC 1的某些核心组分具有负反馈调控作用。最后，ESC-E（Z）复合物对PRC 1组分有正向调节作用。这些交叉调节的多个途径有助于解释Polycomb组基因家族的大规模，但它们使任何单个成员的遗传分析复杂化。
Genes of the Polycomb group in Drosophila melanogaster function as long-term transcriptional repressors. A few members of the group encode proteins found in two evolutionarily conserved chromatin complexes, Polycomb repressive complex 1 (PRC1) and the ESC-E(Z) complex. The majority of the group, lacking clear biochemical functions, might be indirect regulators. The transcript levels of seven Polycomb group genes were assayed in embryos mutant for various other genes in the family. Three Polycomb group genes were identified as upstream positive regulators of the core components of PRC1 There is also negative feedback regulation of some PRC1 core components by other PRC1 genes. Finally, there is positive regulation of PRC1 components by the ESC-E(Z) complex. These multiple pathways of cross-regulation help to explain the large size of the Polycomb group family of genes, but they complicate the genetic analysis of any single member.